Meta-analysis on the association between genetic polymorphisms and prepulse inhibition of the acoustic startle response

Sensorimotor gating measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) has been proposed as one of the most promising electrophysiological endophenotypes of schizophrenia. During the past decade, a number of publications have reported significant associations between geneti...

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Bibliographic Details
Published in:Schizophrenia research 2018-08, Vol.198, p.52-59
Main Authors: Quednow, Boris B., Ejebe, Kenechi, Wagner, Michael, Giakoumaki, Stella G., Bitsios, Panos, Kumari, Veena, Roussos, Panos
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Catechol O-Methyltransferase - genetics
Endophenotype
Gait Disorders, Neurologic - etiology
Gait Disorders, Neurologic - genetics
Gene
Genome-Wide Association Study
Genotype
GluK3 Kainate Receptor
Humans
Intermediate phenotype
Meta-analysis
Mutation
Polymorphism
Polymorphism, Genetic - genetics
Prepulse inhibition
Proline Oxidase - genetics
Psychosis
Receptors, Kainic Acid - genetics
Reflex, Startle - genetics
Schizophrenia
Schizophrenia - complications
Sensorimotor gating
SNP
Startle
Transcription Factor 4 - genetics
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Summary:Sensorimotor gating measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) has been proposed as one of the most promising electrophysiological endophenotypes of schizophrenia. During the past decade, a number of publications have reported significant associations between genetic polymorphisms and PPI in samples of schizophrenia patients and healthy volunteers. However, an overall evaluation of the robustness of these results has not been published so far. Therefore, we performed the first meta-analysis of published and unpublished associations between gene polymorphisms and PPI of ASR. Unpublished associations between genetic polymorphisms and PPI were derived from three independent samples. In total, 120 single observations from 16 independent samples with 2660 study participants and 43 polymorphisms were included. After correction for multiple testing based on false discovery rate and considering the number of analyzed polymorphisms, significant associations were shown for four variants, even though none of these associations survived a genome-wide correction (P
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2017.12.011