Mitochondrial quality control: The role of mitophagy in aging

Autophagy is a catabolic process for eliminating macromolecules and damaged organelles by a highly regulated lysosomal pathway. Importantly, autophagy serves as an integral quality control mechanism by recycling cellular constituents for energy consumption and cellular rejuvenation under basal and s...

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Bibliographic Details
Published in:Trends in cardiovascular medicine 2018-05, Vol.28 (4), p.246-260
Main Authors: Shi, Ruoyang, Guberman, Matthew, Kirshenbaum, Lorrie A.
Format: Article
Language:English
Subjects:
Age
Age Factors
Aging
Aging - metabolism
Aging - pathology
Animals
Apoptosis
Autophagy
Autophagy-Related Proteins - metabolism
Breast cancer
Cell death
Cell division
Defects
Gangrene
Heart diseases
Heart Diseases - metabolism
Heart Diseases - pathology
Heart Diseases - physiopathology
Heart failure
Homeostasis
Humans
Macromolecules
Medical prognosis
Metabolism
Mitochondria
Mitochondria, Heart - metabolism
Mitochondria, Heart - pathology
Mitochondrial Degradation
Mitochondrial DNA
Mitochondrial Dynamics
Mitochondrial dysfunction
Mitophagy
Molecular Chaperones - metabolism
Mutation
Neoplasms - metabolism
Neoplasms - pathology
Nerve Degeneration
Neuroblastoma
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
Neurons - metabolism
Neurons - pathology
Organelle Biogenesis
Organelles
Phagocytosis
Proteins
Quality control
Senescence
Signal Transduction
Ubiquitin-Protein Ligases - metabolism
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Description
Summary:Autophagy is a catabolic process for eliminating macromolecules and damaged organelles by a highly regulated lysosomal pathway. Importantly, autophagy serves as an integral quality control mechanism by recycling cellular constituents for energy consumption and cellular rejuvenation under basal and stress conditions. Nevertheless, there is growing evidence that under certain conditions autophagy can switch from an adaptive survival mechanism to maladaptive process that promotes cell death. Furthermore, defects in autophagy have been linked to mitochondria injury and cell death associated with aging. In this review, we describe the role of autophagy as a physiological mechanism for maintaining homeostasis with its specific involvement in mitochondrial quality control and cardiac aging.
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2017.11.008