Cellular search migrations in normal development and carcinogenesis

This review describes the large group of morphogenetic processes designated as search migrations. Search migrations typically include two stages: i) search, when a group of cells or of the cytoplasmic processes migrate over the cell-free spaces, and ii) choice, the stage when migrating cells reach s...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2006-08, Vol.71 (8), p.821-826
Main Authors: Vasiliev, J M, Gelfand, I M
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - genetics
Apoptosis - physiology
Carcinogenesis
Cell Differentiation
Cell Movement - genetics
Cell Movement - physiology
Genes, p53
Humans
Morphogenesis
Neoplasms - etiology
Neoplasms - genetics
Neoplasms - pathology
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Summary:This review describes the large group of morphogenetic processes designated as search migrations. Search migrations typically include two stages: i) search, when a group of cells or of the cytoplasmic processes migrate over the cell-free spaces, and ii) choice, the stage when migrating cells reach specific loci where they stop and undergo specific differentiations induced by local factors such as cell-cell contacts and humoral agents. Migrating cells that do not meet their targets usually undergo apoptosis. Numerous examples of search migrations range from gastrulation to formation of axon-muscle connections. Critical stages of carcinogenesis such as acquisition of cell ability for invasion may be regarded as the genetic aberration of normal search migration: cancer cells perform an endless search but cannot make final choice.
ISSN:0006-2979
1608-3040
0320-9725
DOI:10.1134/S0006297906080013