Control of tandem isomerizations: flow-assisted reactions of o-lithiated aryl benzyl ethers

Tandem chemical changes are often difficult to control at will, because they proceed rapidly through multiple unstable reactive intermediates. It is desirable to develop a novel method for controlling such tandem changes to obtain desired products with high selectivity. Herein, we report a flow micr...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (5), p.547-550
Main Authors: Lee, Hyune-Jea, Kim, Heejin, Yoshida, Jun-Ichi, Kim, Dong-Pyo
Format: Article
Language:English
Subjects:
Aromatic compounds
Cascade chemical reactions
Chemical reactions
Ethers
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Summary:Tandem chemical changes are often difficult to control at will, because they proceed rapidly through multiple unstable reactive intermediates. It is desirable to develop a novel method for controlling such tandem changes to obtain desired products with high selectivity. Herein, we report a flow microreactor platform for controlling tandem isomerizations of o-lithiated aryl benzyl ethers based on precise residence time control.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc08460a