'Borono-lectin' based engineering as a versatile platform for biomedical applications

Boronic acids are well known for their ability to reversibly interact with the diol groups, a common motif of biomolecules including sugars and ribose. Due to their ability to interact with carbohydrates, they can be regarded as synthetic mimics of lectins, termed 'borono-lectins'. The bor...

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Bibliographic Details
Published in:Science and technology of advanced materials 2018-01, Vol.19 (1), p.18-30
Main Authors: Matsumoto, Akira, Miyahara, Yuji
Format: Article
Language:English
Subjects:
212 Surface and interfaces
30 Bio-inspired and biomedical materials
Biomedical engineering
Biomedical materials
Biomolecules
Boronic acids
borono-lectins
Carbohydrates
diabetes
Drug delivery systems
Focus on Endeavor for Creation of Materials-Tissues Intelligent Interface
insulin
Lectins
Review
Ribose
sialic acids
siRNA
Sugar
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Summary:Boronic acids are well known for their ability to reversibly interact with the diol groups, a common motif of biomolecules including sugars and ribose. Due to their ability to interact with carbohydrates, they can be regarded as synthetic mimics of lectins, termed 'borono-lectins'. The borono-lectins can be tailored to elicit a broad profile of binding strength and specificity. This special property has been translated into many creative biomedical applications in a way interactive with biology. This review provides a brief overview of recent efforts of polymeric materials-based engineering taking advantage of such virtue of 'borono-lectins' chemistry, related to the field of biomaterials and drug delivery applications.
ISSN:1468-6996
1878-5514
DOI:10.1080/14686996.2017.1411143