ORIGINAL ARTICLE: Effects of probiotic bacteria in dogs with food responsive diarrhoea treated with an elimination diet

We evaluated whether a probiotic supplementation in dogs with food responsive diarrhoea (FRD) has beneficial effects on intestinal cytokine patterns and on microbiota. Twenty-one client-owned dogs with FRD were presented for clinically needed duodeno- and colonoscopy and were enrolled in a prospecti...

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Bibliographic Details
Published in:Journal of animal physiology and animal nutrition 2006-08, Vol.90 (7-8), p.269-277
Main Authors: Sauter, S N, Benyacoub, J, Allenspach, K, Gaschen, F, Ontsouka, E, Reuteler, G, Cavadini, C, Knorr, R, Blum, J W
Format: Article
Language:English
Subjects:
Bifidobacterium
Enterobacteriaceae
Enterococcus
Lactobacillus
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Summary:We evaluated whether a probiotic supplementation in dogs with food responsive diarrhoea (FRD) has beneficial effects on intestinal cytokine patterns and on microbiota. Twenty-one client-owned dogs with FRD were presented for clinically needed duodeno- and colonoscopy and were enrolled in a prospective placebo (PL)-controlled probiotic trial. Intestinal tissue samples and faeces were collected during endoscopy. Intestinal mRNA abundance of interleukin (IL)-5, -10, -12p40 and -13, tumour necrosis factor- alpha , transforming growth factor- beta 1 and interferon (IFN)- gamma were analysed and numbers of Lactobacillus spp., Bifidobacterium spp., Enterococcus spp. and Enterobacteriaceae and supplemented probiotic bacteria were determined in faeces. The Canine Inflammatory Bowel Disease Activity Index, a scoring system comprising general attitude, appetite, faecal consistency, defecation frequency, and vomitus, decreased in all dogs (p < 0.0001). Duodenal IL-10 mRNA levels decreased (p = 0.1) and colonic IFN- gamma mRNA levels increased (p = 0.08) after probiotic treatment. Numbers of Enterobacteriaceae decreased in FRD dogs receiving probiotic cocktail (FRD super(PC)) and FRD dogs fed PL (FRD super(PL)) during treatment (p < 0.05), numbers of Lactobacillus spp. increased in FRD super(PC after) when compared with FRD super(PC before) (p < 0.1). One strain of PC was detected in five of eight FRD super(PC) dogs after probiotic supplementation. In conclusion, all dogs clinically improved after treatment, but cytokine patterns were not associated with the clinical features irrespective of the dietary supplementation.
ISSN:0931-2439
1439-0396
DOI:10.1111/j.1439-0396.2005.00595.x