Association of Serum 25(OH) D Levels with Infarct Volumes and Stroke Severity in Acute Ischemic Stroke

• Published in: The Journal of nutrition, health & aging health & aging, 2018, Vol.22 (1), p.97-102
• Main Authors: Li, Y.-Y., Wang, Y.-S., Chen, Y., Hu, Y.-H., Cui, W., Shi, X.-Y., Jiang, W., Zhang, Jian-min
• Format: Article
• Language: English
• Subjects: Acute Disease; Aged; Aging; Brain Ischemia - blood; Brain Ischemia - diagnostic imaging; Brain Ischemia - pathology; Diffusion Magnetic Resonance Imaging; Female; Geriatrics/Gerontology; Humans; Ischemia; Male; Medicine; Medicine & Public Health; Middle Aged; Neurosciences; Nutrition; Primary Care Medicine; Quality of Life Research; Retrospective Studies; Risk Factors; Severity of Illness Index; Stroke; Stroke - blood; Stroke - complications; Stroke - diagnostic imaging; Stroke - pathology; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; Vitamin D Deficiency - diagnostic imaging; Vitamin D Deficiency - pathology
• ISSN: 1279-7707; 1760-4788
• DOI: 10.1007/s12603-017-0926-z

Background The aim of this study is to investigate whether 25-hydroxyvitamin D [25(OH) D] is associated with initial stroke severity and infarct volume, using diffusion-weighted imaging (DWI) in patients with acute ischemic stroke. Methods We studied a total of 235 patients who were admitted within 24 hours of acute ischemic stroke onset. Initial stroke severity was assessed using the NIH Stroke Scale (NIHSS) score. Infarct volume was measured using DWI. Multivariable linear and logistic regression analyses were used to test whether 25(OH) D represents an independent predictor of infarct volume and stroke severity (NIHSS score of ≥6). Results Among 235 study patients, the median age was 64 years (IQR 56-75 years), and 125 (53.2%) were women. In multivariable models adjusted for other significant risk factors, 25(OH) D levels in the lowest and second interquartiles were associated with an increased risk of a NIHSS≥6 (with highest 25 (OH) D quartile as reference) with odd ratios (OR) 3.02(95% confidence interval [CI]:1.59-6.34) and 5.85(2.90-11.54). The median DWI infarct volumes for the serum 25(OH) D level quartiles (lowest to highest) were 12.35, 6.55, 2.44, and 1.59 ml. The median DWI infarct volume in the lowest serum 25(OH) D level quartile was larger than that in the other 3 quartiles (P