Synthesis and structure–activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents

We herein report the synthesis, biological activity and preliminary structure–activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead c...

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Bibliographic Details
Published in:Molecular diversity 2018-05, Vol.22 (2), p.323-333
Main Authors: Yan, Longjia, Wang, Hui, Chen, Yunpeng, Li, Zhiwei, Pei, Yazhong
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Azepines - chemical synthesis
Azepines - chemistry
Azepines - pharmacology
Biochemistry
Biomedical and Life Sciences
Cancer therapies
Cellular biology
Chemical compounds
Chemical synthesis
Chemistry Techniques, Synthetic
HeLa Cells
Humans
Life Sciences
Molecular structure
Organic Chemistry
Original Article
Pharmacy
Polymer Sciences
Structure-Activity Relationship
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Summary:We herein report the synthesis, biological activity and preliminary structure–activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds 7j and 7k at 3 μ M concentration, cell arrest was observed in the G2/M phase. Graphical Abstract
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-017-9805-0