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Analysis of circulating extracellular vesicle-associated microRNAs in cortisol-producing adrenocortical tumors
Purpose Circulating microRNAs (miRNA) have been described in patients with adrenocortical tumors, but the expression of miRNAs in non-functioning and cortisol-producing tumors has not been yet compared. Therefore, the objective of this study was to evaluate the expression of plasma extracellular ves...
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| Published in: | Endocrine 2018-02, Vol.59 (2), p.280-287 |
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| container_issue | 2 |
| container_start_page | 280 |
| container_title | Endocrine |
| container_volume | 59 |
| creator | Perge, Pál Decmann, Ábel Pezzani, Raffaele Bancos, Irina Fassina, Ambrogio Luconi, Michaela Canu, Letizia Tóth, Miklós Boscaro, Marco Patócs, Attila Igaz, Peter |
| description | Purpose
Circulating microRNAs (miRNA) have been described in patients with adrenocortical tumors, but the expression of miRNAs in non-functioning and cortisol-producing tumors has not been yet compared. Therefore, the objective of this study was to evaluate the expression of plasma extracellular vesicle (EV)-associated microRNAs in patients with non-functioning adrenocortical adenoma (NFA), cortisol-producing adrenocortical adenoma (CPA) and cortisol-producing adrenocortical carcinoma (CP-ACC).
Methods
Preoperative plasma EV samples of 13 NFAs, 13 CPAs and 9 CP-ACCs were subjected to extracellular vesicle isolation. miRNAs were investigated by targeted quantitative real-time PCR normalized to cel-miR-39 as reference. Five miRNAs have been selected for this analysis based on the previous studies including hsa-miR-22-3p, hsa-miR-27a-3p, hsa-miR-210-3p, hsa-miR-320b and hsa-miR-375.
Results
We have observed significant overrepresentation of three miRNAs in both CPA and CP-ACC relative to NFA: hsa-miR-22-3p (
p
|
| doi_str_mv | 10.1007/s12020-017-1506-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1984753539</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1984753539</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-f727344106a352b7a4705dabbee51373d0a0721d6a4725b7f866fa1aa06664293</originalsourceid><addsrcrecordid>eNp1kc1q3TAQhUVJadK0D9BNMWTTjdqRZEnXy0tIfyA0EBLIToxlOSjYVqqxQ3OfvnJvWkohK4k53xxp5jD2TsBHAWA_kZAggYOwXGgwfPeCHQmtm1IBOCh3pTUH2NwcstdEdwBSSmNfsUPZyKaxjTli03bC4ZEiVamvfMx-GXCO020Vfs4ZfRiGUsjVQ6Doh8CRKPmIc-iqMfqcLr9vqYpT5VOeI6WB3-fULX41wC6HKf0WPA7VvIwp0xv2sseBwtun85hdfz67Ov3Kzy--fDvdnnNfb8TMeyutqmsBBpWWrcXagu6wbUPQQlnVAYKVojNFkLq1_caYHgUiGGNq2ahj9mHvW_7zYwk0uzHSOg1OIS3kRLOprVZarejJf-hdWnLZyko1CmqAeqXEnipDE-XQu_scR8yPToBbw3D7MFwJw61huF3pef_kvLRj6P52_Nl-AeQeoCJNtyH_8_Szrr8AvN2WZg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1993040049</pqid></control><display><type>article</type><title>Analysis of circulating extracellular vesicle-associated microRNAs in cortisol-producing adrenocortical tumors</title><source>Springer Nature</source><creator>Perge, Pál ; Decmann, Ábel ; Pezzani, Raffaele ; Bancos, Irina ; Fassina, Ambrogio ; Luconi, Michaela ; Canu, Letizia ; Tóth, Miklós ; Boscaro, Marco ; Patócs, Attila ; Igaz, Peter</creator><creatorcontrib>Perge, Pál ; Decmann, Ábel ; Pezzani, Raffaele ; Bancos, Irina ; Fassina, Ambrogio ; Luconi, Michaela ; Canu, Letizia ; Tóth, Miklós ; Boscaro, Marco ; Patócs, Attila ; Igaz, Peter</creatorcontrib><description><![CDATA[Purpose
Circulating microRNAs (miRNA) have been described in patients with adrenocortical tumors, but the expression of miRNAs in non-functioning and cortisol-producing tumors has not been yet compared. Therefore, the objective of this study was to evaluate the expression of plasma extracellular vesicle (EV)-associated microRNAs in patients with non-functioning adrenocortical adenoma (NFA), cortisol-producing adrenocortical adenoma (CPA) and cortisol-producing adrenocortical carcinoma (CP-ACC).
Methods
Preoperative plasma EV samples of 13 NFAs, 13 CPAs and 9 CP-ACCs were subjected to extracellular vesicle isolation. miRNAs were investigated by targeted quantitative real-time PCR normalized to cel-miR-39 as reference. Five miRNAs have been selected for this analysis based on the previous studies including hsa-miR-22-3p, hsa-miR-27a-3p, hsa-miR-210-3p, hsa-miR-320b and hsa-miR-375.
Results
We have observed significant overrepresentation of three miRNAs in both CPA and CP-ACC relative to NFA: hsa-miR-22-3p (
p
< 0.01 and
p
< 0.0001, respectively), hsa-miR-27a-3p (
p
< 0.05 in both comparisons) and hsa-miR-320b (
p
< 0.05 and
p
< 0.0001, respectively). Hsa-miR-320b has been significantly overrepresented in CP-ACC relative to CPA (
p
< 0.01). Hsa-miR-210-3p turned out to be significantly overrepresented only in CP-ACC compared to NFA (
p
< 0.05). Significant correlation was revealed between circulating miRNA concentrations and urinary free cortisol values for hsa-miR-22-3p, hsa-miR-27a-3p and hsa-miR-320b (
p
< 0.0001 for all) and cortisol after low-dose dexamethasone test for hsa-miR-22-3p and hsa-miR-320b (
p
< 0.05). Hsa-miR-27a-3p has been significantly stimulated by low-dose dexamethasone test (
p
< 0.05).
Conclusions
EV-associated miRNAs are differentially expressed in different non-functioning and cortisol-producing adrenocortical tumors.]]></description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-017-1506-z</identifier><identifier>PMID: 29299796</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adenoma ; Adrenal Cortex Neoplasms - genetics ; Adrenal Cortex Neoplasms - metabolism ; Adrenocortical Adenoma - genetics ; Adrenocortical Adenoma - metabolism ; Adrenocortical Carcinoma - genetics ; Adrenocortical Carcinoma - metabolism ; Adult ; Aged ; Aged, 80 and over ; Circulating MicroRNA - genetics ; Circulating MicroRNA - metabolism ; Cortisol ; Dexamethasone ; Diabetes ; Endocrine Genetics/Epigenetics ; Endocrinology ; Extracellular Vesicles - metabolism ; Female ; Hormones ; Humanities and Social Sciences ; Humans ; Hydrocortisone - metabolism ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; MicroRNAs ; Middle Aged ; miRNA ; multidisciplinary ; Science ; Tumors ; Young Adult</subject><ispartof>Endocrine, 2018-02, Vol.59 (2), p.280-287</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-f727344106a352b7a4705dabbee51373d0a0721d6a4725b7f866fa1aa06664293</citedby><cites>FETCH-LOGICAL-c481t-f727344106a352b7a4705dabbee51373d0a0721d6a4725b7f866fa1aa06664293</cites><orcidid>0000-0002-4635-8644 ; 0000-0003-3156-2500 ; 0000-0001-5186-064X ; 0000-0002-0722-7684 ; 0000-0002-8701-408X ; 0000-0001-9332-2524 ; 0000-0003-2596-1652 ; 0000-0003-4995-8108 ; 0000-0001-7506-674X ; 0000-0003-2192-554X ; 0000-0002-5737-2249</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29299796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perge, Pál</creatorcontrib><creatorcontrib>Decmann, Ábel</creatorcontrib><creatorcontrib>Pezzani, Raffaele</creatorcontrib><creatorcontrib>Bancos, Irina</creatorcontrib><creatorcontrib>Fassina, Ambrogio</creatorcontrib><creatorcontrib>Luconi, Michaela</creatorcontrib><creatorcontrib>Canu, Letizia</creatorcontrib><creatorcontrib>Tóth, Miklós</creatorcontrib><creatorcontrib>Boscaro, Marco</creatorcontrib><creatorcontrib>Patócs, Attila</creatorcontrib><creatorcontrib>Igaz, Peter</creatorcontrib><title>Analysis of circulating extracellular vesicle-associated microRNAs in cortisol-producing adrenocortical tumors</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description><![CDATA[Purpose
Circulating microRNAs (miRNA) have been described in patients with adrenocortical tumors, but the expression of miRNAs in non-functioning and cortisol-producing tumors has not been yet compared. Therefore, the objective of this study was to evaluate the expression of plasma extracellular vesicle (EV)-associated microRNAs in patients with non-functioning adrenocortical adenoma (NFA), cortisol-producing adrenocortical adenoma (CPA) and cortisol-producing adrenocortical carcinoma (CP-ACC).
Methods
Preoperative plasma EV samples of 13 NFAs, 13 CPAs and 9 CP-ACCs were subjected to extracellular vesicle isolation. miRNAs were investigated by targeted quantitative real-time PCR normalized to cel-miR-39 as reference. Five miRNAs have been selected for this analysis based on the previous studies including hsa-miR-22-3p, hsa-miR-27a-3p, hsa-miR-210-3p, hsa-miR-320b and hsa-miR-375.
Results
We have observed significant overrepresentation of three miRNAs in both CPA and CP-ACC relative to NFA: hsa-miR-22-3p (
p
< 0.01 and
p
< 0.0001, respectively), hsa-miR-27a-3p (
p
< 0.05 in both comparisons) and hsa-miR-320b (
p
< 0.05 and
p
< 0.0001, respectively). Hsa-miR-320b has been significantly overrepresented in CP-ACC relative to CPA (
p
< 0.01). Hsa-miR-210-3p turned out to be significantly overrepresented only in CP-ACC compared to NFA (
p
< 0.05). Significant correlation was revealed between circulating miRNA concentrations and urinary free cortisol values for hsa-miR-22-3p, hsa-miR-27a-3p and hsa-miR-320b (
p
< 0.0001 for all) and cortisol after low-dose dexamethasone test for hsa-miR-22-3p and hsa-miR-320b (
p
< 0.05). Hsa-miR-27a-3p has been significantly stimulated by low-dose dexamethasone test (
p
< 0.05).
Conclusions
EV-associated miRNAs are differentially expressed in different non-functioning and cortisol-producing adrenocortical tumors.]]></description><subject>Adenoma</subject><subject>Adrenal Cortex Neoplasms - genetics</subject><subject>Adrenal Cortex Neoplasms - metabolism</subject><subject>Adrenocortical Adenoma - genetics</subject><subject>Adrenocortical Adenoma - metabolism</subject><subject>Adrenocortical Carcinoma - genetics</subject><subject>Adrenocortical Carcinoma - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Circulating MicroRNA - genetics</subject><subject>Circulating MicroRNA - metabolism</subject><subject>Cortisol</subject><subject>Dexamethasone</subject><subject>Diabetes</subject><subject>Endocrine Genetics/Epigenetics</subject><subject>Endocrinology</subject><subject>Extracellular Vesicles - metabolism</subject><subject>Female</subject><subject>Hormones</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hydrocortisone - metabolism</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MicroRNAs</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>multidisciplinary</subject><subject>Science</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc1q3TAQhUVJadK0D9BNMWTTjdqRZEnXy0tIfyA0EBLIToxlOSjYVqqxQ3OfvnJvWkohK4k53xxp5jD2TsBHAWA_kZAggYOwXGgwfPeCHQmtm1IBOCh3pTUH2NwcstdEdwBSSmNfsUPZyKaxjTli03bC4ZEiVamvfMx-GXCO020Vfs4ZfRiGUsjVQ6Doh8CRKPmIc-iqMfqcLr9vqYpT5VOeI6WB3-fULX41wC6HKf0WPA7VvIwp0xv2sseBwtun85hdfz67Ov3Kzy--fDvdnnNfb8TMeyutqmsBBpWWrcXagu6wbUPQQlnVAYKVojNFkLq1_caYHgUiGGNq2ahj9mHvW_7zYwk0uzHSOg1OIS3kRLOprVZarejJf-hdWnLZyko1CmqAeqXEnipDE-XQu_scR8yPToBbw3D7MFwJw61huF3pef_kvLRj6P52_Nl-AeQeoCJNtyH_8_Szrr8AvN2WZg</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Perge, Pál</creator><creator>Decmann, Ábel</creator><creator>Pezzani, Raffaele</creator><creator>Bancos, Irina</creator><creator>Fassina, Ambrogio</creator><creator>Luconi, Michaela</creator><creator>Canu, Letizia</creator><creator>Tóth, Miklós</creator><creator>Boscaro, Marco</creator><creator>Patócs, Attila</creator><creator>Igaz, Peter</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4635-8644</orcidid><orcidid>https://orcid.org/0000-0003-3156-2500</orcidid><orcidid>https://orcid.org/0000-0001-5186-064X</orcidid><orcidid>https://orcid.org/0000-0002-0722-7684</orcidid><orcidid>https://orcid.org/0000-0002-8701-408X</orcidid><orcidid>https://orcid.org/0000-0001-9332-2524</orcidid><orcidid>https://orcid.org/0000-0003-2596-1652</orcidid><orcidid>https://orcid.org/0000-0003-4995-8108</orcidid><orcidid>https://orcid.org/0000-0001-7506-674X</orcidid><orcidid>https://orcid.org/0000-0003-2192-554X</orcidid><orcidid>https://orcid.org/0000-0002-5737-2249</orcidid></search><sort><creationdate>20180201</creationdate><title>Analysis of circulating extracellular vesicle-associated microRNAs in cortisol-producing adrenocortical tumors</title><author>Perge, Pál ; Decmann, Ábel ; Pezzani, Raffaele ; Bancos, Irina ; Fassina, Ambrogio ; Luconi, Michaela ; Canu, Letizia ; Tóth, Miklós ; Boscaro, Marco ; Patócs, Attila ; Igaz, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-f727344106a352b7a4705dabbee51373d0a0721d6a4725b7f866fa1aa06664293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenoma</topic><topic>Adrenal Cortex Neoplasms - genetics</topic><topic>Adrenal Cortex Neoplasms - metabolism</topic><topic>Adrenocortical Adenoma - genetics</topic><topic>Adrenocortical Adenoma - metabolism</topic><topic>Adrenocortical Carcinoma - genetics</topic><topic>Adrenocortical Carcinoma - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Circulating MicroRNA - genetics</topic><topic>Circulating MicroRNA - metabolism</topic><topic>Cortisol</topic><topic>Dexamethasone</topic><topic>Diabetes</topic><topic>Endocrine Genetics/Epigenetics</topic><topic>Endocrinology</topic><topic>Extracellular Vesicles - metabolism</topic><topic>Female</topic><topic>Hormones</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hydrocortisone - metabolism</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>MicroRNAs</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>multidisciplinary</topic><topic>Science</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perge, Pál</creatorcontrib><creatorcontrib>Decmann, Ábel</creatorcontrib><creatorcontrib>Pezzani, Raffaele</creatorcontrib><creatorcontrib>Bancos, Irina</creatorcontrib><creatorcontrib>Fassina, Ambrogio</creatorcontrib><creatorcontrib>Luconi, Michaela</creatorcontrib><creatorcontrib>Canu, Letizia</creatorcontrib><creatorcontrib>Tóth, Miklós</creatorcontrib><creatorcontrib>Boscaro, Marco</creatorcontrib><creatorcontrib>Patócs, Attila</creatorcontrib><creatorcontrib>Igaz, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perge, Pál</au><au>Decmann, Ábel</au><au>Pezzani, Raffaele</au><au>Bancos, Irina</au><au>Fassina, Ambrogio</au><au>Luconi, Michaela</au><au>Canu, Letizia</au><au>Tóth, Miklós</au><au>Boscaro, Marco</au><au>Patócs, Attila</au><au>Igaz, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of circulating extracellular vesicle-associated microRNAs in cortisol-producing adrenocortical tumors</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>59</volume><issue>2</issue><spage>280</spage><epage>287</epage><pages>280-287</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract><![CDATA[Purpose
Circulating microRNAs (miRNA) have been described in patients with adrenocortical tumors, but the expression of miRNAs in non-functioning and cortisol-producing tumors has not been yet compared. Therefore, the objective of this study was to evaluate the expression of plasma extracellular vesicle (EV)-associated microRNAs in patients with non-functioning adrenocortical adenoma (NFA), cortisol-producing adrenocortical adenoma (CPA) and cortisol-producing adrenocortical carcinoma (CP-ACC).
Methods
Preoperative plasma EV samples of 13 NFAs, 13 CPAs and 9 CP-ACCs were subjected to extracellular vesicle isolation. miRNAs were investigated by targeted quantitative real-time PCR normalized to cel-miR-39 as reference. Five miRNAs have been selected for this analysis based on the previous studies including hsa-miR-22-3p, hsa-miR-27a-3p, hsa-miR-210-3p, hsa-miR-320b and hsa-miR-375.
Results
We have observed significant overrepresentation of three miRNAs in both CPA and CP-ACC relative to NFA: hsa-miR-22-3p (
p
< 0.01 and
p
< 0.0001, respectively), hsa-miR-27a-3p (
p
< 0.05 in both comparisons) and hsa-miR-320b (
p
< 0.05 and
p
< 0.0001, respectively). Hsa-miR-320b has been significantly overrepresented in CP-ACC relative to CPA (
p
< 0.01). Hsa-miR-210-3p turned out to be significantly overrepresented only in CP-ACC compared to NFA (
p
< 0.05). Significant correlation was revealed between circulating miRNA concentrations and urinary free cortisol values for hsa-miR-22-3p, hsa-miR-27a-3p and hsa-miR-320b (
p
< 0.0001 for all) and cortisol after low-dose dexamethasone test for hsa-miR-22-3p and hsa-miR-320b (
p
< 0.05). Hsa-miR-27a-3p has been significantly stimulated by low-dose dexamethasone test (
p
< 0.05).
Conclusions
EV-associated miRNAs are differentially expressed in different non-functioning and cortisol-producing adrenocortical tumors.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>29299796</pmid><doi>10.1007/s12020-017-1506-z</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4635-8644</orcidid><orcidid>https://orcid.org/0000-0003-3156-2500</orcidid><orcidid>https://orcid.org/0000-0001-5186-064X</orcidid><orcidid>https://orcid.org/0000-0002-0722-7684</orcidid><orcidid>https://orcid.org/0000-0002-8701-408X</orcidid><orcidid>https://orcid.org/0000-0001-9332-2524</orcidid><orcidid>https://orcid.org/0000-0003-2596-1652</orcidid><orcidid>https://orcid.org/0000-0003-4995-8108</orcidid><orcidid>https://orcid.org/0000-0001-7506-674X</orcidid><orcidid>https://orcid.org/0000-0003-2192-554X</orcidid><orcidid>https://orcid.org/0000-0002-5737-2249</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Endocrine, 2018-02, Vol.59 (2), p.280-287 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_1984753539 |
| source | Springer Nature |
| subjects | Adenoma Adrenal Cortex Neoplasms - genetics Adrenal Cortex Neoplasms - metabolism Adrenocortical Adenoma - genetics Adrenocortical Adenoma - metabolism Adrenocortical Carcinoma - genetics Adrenocortical Carcinoma - metabolism Adult Aged Aged, 80 and over Circulating MicroRNA - genetics Circulating MicroRNA - metabolism Cortisol Dexamethasone Diabetes Endocrine Genetics/Epigenetics Endocrinology Extracellular Vesicles - metabolism Female Hormones Humanities and Social Sciences Humans Hydrocortisone - metabolism Internal Medicine Male Medicine Medicine & Public Health MicroRNAs Middle Aged miRNA multidisciplinary Science Tumors Young Adult |
| title | Analysis of circulating extracellular vesicle-associated microRNAs in cortisol-producing adrenocortical tumors |
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