Autoimmune Thrombocytopenia in Chronic Myeloid Leukemia Treated with Interferon-alpha: Differential Diagnosis and Possible Pathogenesis

Interferon-α (INF-α) is an effective anti-neoplastic and anti-viral drug. Treatment with INF-α is frequently complicated by adverse effects, which may rarely be immune mediated. We report 2 patients with Ph+ chronic myeloid leukemia (CML) who developed autoimmune thrombocytopenia while receiving mon...

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Bibliographic Details
Published in:Leukemia & lymphoma 2003-12, Vol.44 (12), p.2103-2108
Main Authors: Herishanu, Yair, Trestman, Svetlana, Kirgner, Ilya, Rachmani, Rodica, Naparstek, Ella
Format: Article
Language:English
Subjects:
Adult
Aged
Autoimmune Diseases - diagnosis
Autoimmune Diseases - pathology
Autoimmune thrombocytopenia
Chronic myeloid leukemia
Diagnosis, Differential
Female
Humans
Interferon-alpha - adverse effects
Interferon-α
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy
Male
Middle Aged
Models, Biological
Thrombocytopenia - diagnosis
Thrombocytopenia - pathology
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Summary:Interferon-α (INF-α) is an effective anti-neoplastic and anti-viral drug. Treatment with INF-α is frequently complicated by adverse effects, which may rarely be immune mediated. We report 2 patients with Ph+ chronic myeloid leukemia (CML) who developed autoimmune thrombocytopenia while receiving months of treatment with INF-α. This complication responded well to discontinuation of interferon and administration of steroids treatment. Here, we also summarize the literature on INF-α induced autoimmune thrombocytopenia, and discuss differential diagnosis and possible mechanisms involved in the development of thrombocytopenia during therapy with INF-α.
ISSN:1042-8194
1029-2403
DOI:10.1080/1042819031000123447