ORIGINAL ARTICLE: Association of interleukin-1 beta polymorphism with recurrent aphthous stomatitis in Brazilian individuals

• Published in: Oral diseases 2006-11, Vol.12 (6), p.580-583
• Main Authors: Guimaraes, ALS, de Sa, AR, Victoria, JMN, Correia-Silva, J F, Pessoa, P S, Diniz, M G, Gomez, R S
• Format: Article
• Language: English
• ISSN: 1354-523X; 1601-0825
• DOI: 10.1111/j.1601-0825.2006.01243.x

Background:Recurrent aphthous stomatitis (RAS) is characterized by recurrent episodes of oral ulceration in an otherwise healthy individual. Some reports in the literature indicate that RAS may have immunological, psychological, genetic and microbiological bases. The purpose of the present study was to investigate the possible association between interleukin-1 beta (IL-1 beta ) +3954 (C/T) genetic polymorphism and RAS in a sample of Brazilian patients. Subjects and methods:Sixty-two consecutive subjects affected by minor and major forms of RAS and 62 healthy volunteers were genotyped at IL-1 beta (+3954). The chi-squared test was used for statistical analysis. Results:A significant increase in the high production of IL-1 beta genotype CT was observed in the group with RAS (P = 0.01). After stratifying RAS patients according to the mean number of lesions per episode, a significant difference was only observed between patients with greater than or equal to 3 lesions in each episode and control. Conclusion:There is an increased frequency of polymorphism associated with high IL-1 beta production in RAS patients.