Effect of antiviral treatment and host susceptibility on positive selection in hepatitis C virus (HCV)

We have conducted a large sequence study of the E1–E2 and NS5A regions of the HCV, subtypes 1a and b, both in patients previously treated with interferon, and untreated patients, who later responded, or not, to a combination therapy based on interferon plus ribavirin. We have examined the role playe...

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Bibliographic Details
Published in:Virus research 2008-02, Vol.131 (2), p.224-232
Main Authors: Jiménez-Hernández, Nuria, Sentandreu, Vicente, Castro, José A., Torres-Puente, Manuela, Bracho, Alma, García-Robles, Inmaculada, Ortega, Enrique, del Olmo, Juan, Carnicer, Fernando, González-Candelas, Fernando, Moya, Andrés
Format: Article
Language:English
Subjects:
Adult
Aged
Amino Acid Sequence
Amino Acid Substitution
Antiviral Agents - therapeutic use
E1–E2 region
Female
HCV
Hepacivirus - drug effects
Hepacivirus - genetics
Hepacivirus - isolation & purification
Hepatitis C - drug therapy
Hepatitis C - virology
Hepatitis C virus
Host genetic factors
Humans
Interferon treatment
Interferons - therapeutic use
Male
Middle Aged
Molecular Sequence Data
NS5A region
Positive selection
Response to combination therapy based on interferon plus ribavirin
Ribavirin - therapeutic use
RNA, Viral - genetics
Selection, Genetic
Sequence Analysis, DNA
Treatment Outcome
Viral Envelope Proteins - genetics
Viral Nonstructural Proteins - genetics
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Summary:We have conducted a large sequence study of the E1–E2 and NS5A regions of the HCV, subtypes 1a and b, both in patients previously treated with interferon, and untreated patients, who later responded, or not, to a combination therapy based on interferon plus ribavirin. We have examined the role played by the number of positively selected sites on disease progression and its relationship with several variables such as patients’ age, sex and their risk of acquiring the disease. We have detected three groups of patients that respond or not to combination therapy: responders of intermediate age, older non-responders and young non-responders, they possess an increasing average number of positively selected sites in the E1–E2 region, respectively. We conclude that the host's genetic factors play an important role in whether the disease is contained or becomes chronic.
ISSN:0168-1702
1872-7492
DOI:10.1016/j.virusres.2007.09.012