Noninvasive follicular thyroid neoplasm with papillary‐like nuclear features in the pediatric age group

BACKGROUND The most common malignant thyroid neoplasm in children is papillary thyroid carcinoma (PTC). In 2015, the Endocrine Pathology Society introduced the terminology “noninvasive follicular thyroid neoplasm with papillary‐like nuclear features” (NIFTP) to replace the noninvasive follicular var...

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Published in:Cancer cytopathology 2018-01, Vol.126 (1), p.27-35
Main Authors: Rossi, Esther Diana, Mehrotra, Swati, Kilic, Ayse Irem, Toslak, Iclal Erdem, Lim‐Dunham, Jennifer, Martini, Maurizio, Fadda, Guido, Lombardi, Celestino Pio, Larocca, Luigi Maria, Barkan, Güliz A.
Format: Article
Language:English
Subjects:
Adenocarcinoma, Follicular - pathology
BRAF mutation
Cell Nucleus - pathology
Cellular biology
Child
Humans
noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP)
noninvasive follicular variant of papillary thyroid carcinoma
pediatric thyroid lesions
Pediatrics
Population
Terminology
Thyroid cancer
Thyroid Cancer, Papillary - pathology
thyroid carcinoma
Thyroid Neoplasms - pathology
Tumors
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Summary:BACKGROUND The most common malignant thyroid neoplasm in children is papillary thyroid carcinoma (PTC). In 2015, the Endocrine Pathology Society introduced the terminology “noninvasive follicular thyroid neoplasm with papillary‐like nuclear features” (NIFTP) to replace the noninvasive follicular variant of PTC. The objective of the current study was to evaluate previously diagnosed PTC in the pediatric population, reappraise it for NIFTP, and discuss the impact of NIFTP on the risk of malignancy (ROM) for each The Bethesda System for Reporting Thyroid Cytopathology category in the pediatric population. METHODS The electronic databases of both study institutions were searched for all thyroidectomy specimens in patients aged
ISSN:1934-662X
1934-6638
DOI:10.1002/cncy.21933