Analysis of lipid metabolism and its impact on the risk of ischemic heart disease in patients with definite familial hypercholesterolemia

to analyze the relationship between lipid disturbance, including lipoprotein(a) (Lp(a)) levels, and development of ischemic heart disease (IHD) in patients with familial hypercholesterolemia (FH). 81 patients (middle age was 39.1 ± 0.4 years, 33 males, 48 females) with a definite FH were examined. T...

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Bibliographic Details
Published in:Atherosclerosis. Supplements 2017-11, Vol.30, p.56-62
Main Authors: Korneva, Viktoria, Kuznetsova, Tatiana, Julius, Ulrich
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biomarkers - blood
Familial hypercholesterolemia
Female
Humans
Hyperlipoproteinemia Type II - blood
Hyperlipoproteinemia Type II - diagnosis
Hyperlipoproteinemia Type II - epidemiology
Hyperlipoproteinemia Type II - genetics
Incidence
Ischemic heart disease
Lipid Metabolism
Lipoprotein(a)
Lipoprotein(a) - blood
Male
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - epidemiology
Myocardial Ischemia - blood
Myocardial Ischemia - diagnosis
Myocardial Ischemia - epidemiology
Myocardial Ischemia - genetics
Prognosis
Registries
Risk Assessment
Risk Factors
Russia - epidemiology
Up-Regulation
Young Adult
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Summary:to analyze the relationship between lipid disturbance, including lipoprotein(a) (Lp(a)) levels, and development of ischemic heart disease (IHD) in patients with familial hypercholesterolemia (FH). 81 patients (middle age was 39.1 ± 0.4 years, 33 males, 48 females) with a definite FH were examined. The concentration of Lp(a) was determined by immunoturbidimetric method. Lipid profiles were estimated by enzymatic colorimetric method. Lp(a) levels were elevated in 41.9% of FH patients. In FH patients with elevated Lp(a) (>0.3 g/l) IHD occurred 1.7 times more often, myocardial infarction – 2.76 times. The risk of IHD in FH patients was increased in individuals with Lp(a) 1.2 g/l and above. Lp(a) elevation plays an additional role in IHD appearance in FH.
ISSN:1567-5688
1878-5050
DOI:10.1016/j.atherosclerosissup.2017.05.008