Effect of sufentanil on bispectral index in the elderly

Summary We examined the impact of adding sufentanil during anaesthesia induction with propofol on bispectral index values in elderly patients (≥ 65 years). Patients were randomly assigned to receive a target‐controlled sufentanil infusion (effect‐site concentration of 0.3 ng.ml−1) or matching placeb...

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Bibliographic Details
Published in:Anaesthesia 2018-02, Vol.73 (2), p.216-222
Main Authors: Valence, T., Elia, N., Czarnetzki, C., Dumont, L., Tramèr, M. R., Lysakowski, C.
Format: Article
Language:English
Subjects:
Alertness
Anesthesia
Confidence intervals
Consciousness
EEG
elderly
Geriatrics
monitoring
Older people
opioids
Patients
Propofol
Sufentanil
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Summary:Summary We examined the impact of adding sufentanil during anaesthesia induction with propofol on bispectral index values in elderly patients (≥ 65 years). Patients were randomly assigned to receive a target‐controlled sufentanil infusion (effect‐site concentration of 0.3 ng.ml−1) or matching placebo, followed by a target‐controlled propofol induction (initial effect‐site concentration of 0.5 μg.ml−1; step‐wise increase of 0.5 μg.ml−1) until loss of consciousness defined as an Observer's Assessment of Alertness/Sedation score < 2. Seventy‐one patients (sufentanil 35, placebo 36) completed the study. Mean (SD) age was 72.3 (5.8) years; 41% were women. At loss of consciousness, mean (SD) bispectral index value was 75.0 (8.6) with sufentanil and 70.0 (8.0) with placebo; mean difference −5.0 (95% confidence interval −8.9 to −1.1), p = 0.013. Post‐hoc analyses suggest that the difference was significant in men only (mean difference −7.3 (−11.8 to −2.6), p = 0.003). Sufentanil co‐induction with propofol results in higher bispectral index values at loss of consciousness in elderly patients.
ISSN:0003-2409
1365-2044
DOI:10.1111/anae.14102