SLAM-Associated Protein Solves a Mystery of Autoimmunity

:  SLAM‐associated protein (SAP) is essential for viral protection, lifelong immune memory (vaccination), and lifelong autoantibody production. We discuss how SAP is a key player in the development of autoimmune disease.

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2007-08, Vol.1109 (1), p.19-30
Main Authors: SAWADA, SHIGEMASA, TAKEI, MASAMI, ISHIWATA, TETSUYOSI, SHIRAIWA, HIDETAKA, INOMATA, HIROTAKE, NOZAKI, TAKAMASA
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - pathology
autoimmune disease
Autoimmunity - immunology
Cloning, Molecular
Glomerulonephritis, IGA - genetics
Glomerulonephritis, IGA - immunology
Humans
IgA nephropathy
Intracellular Signaling Peptides and Proteins - genetics
Intracellular Signaling Peptides and Proteins - immunology
Lymphocytes - metabolism
Lymphoproliferative Disorders - genetics
Lymphoproliferative Disorders - immunology
rheumatoid arthritis
SAP knockout mice
SLAM-associated protein (SAP)
X-linked lymphoproliferative syndrome
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Description
Summary::  SLAM‐associated protein (SAP) is essential for viral protection, lifelong immune memory (vaccination), and lifelong autoantibody production. We discuss how SAP is a key player in the development of autoimmune disease.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1196/annals.1398.003