Oxidative stress and its effects during dehydration

Water is usually thought to be required for the living state, but several organisms are capable of surviving complete dehydration (anhydrobiotes). Elucidation of the mechanisms of tolerance against dehydration may lead to development of new methods for preserving biological materials that do not nor...

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Bibliographic Details
Published in:Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2007-04, Vol.146 (4), p.621-631
Main Authors: França, M.B., Panek, A.D., Eleutherio, E.C.A.
Format: Article
Language:English
Subjects:
Anhydrobiotes
Animals
Antioxidants - metabolism
Catalase
Catalase - metabolism
Dehydration
DNA Damage
Glutathione
Glutathione - metabolism
Lipid Metabolism
Lipid Peroxidation
Oxidation
Oxidative Stress
Proteins - metabolism
Reactive Oxygen Species
ROS
Saccharomyces cerevisiae
Saccharomyces cerevisiae - physiology
Superoxide dismutase
Superoxide Dismutase - metabolism
Trehalose
Trehalose - metabolism
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Summary:Water is usually thought to be required for the living state, but several organisms are capable of surviving complete dehydration (anhydrobiotes). Elucidation of the mechanisms of tolerance against dehydration may lead to development of new methods for preserving biological materials that do not normally support drying, which is of enormous practical importance in industry, in clinical medicine as well as in agriculture. One of the molecular mechanisms of damage leading to death in desiccation-sensitive cells upon drying is free-radical attack to phospholipids, DNA and proteins. This review aims to summarize the strategies used by anhydrobiotes to cope with the danger of oxygen toxicity and to present our recent results about the importance of some antioxidant defense systems in the dehydration tolerance of Saccharomyces cerevisiae, a usual model in the study of stress response.
ISSN:1095-6433
1531-4332
DOI:10.1016/j.cbpa.2006.02.030