Inflammatory markers in the patients of Japanese encephalitis

Objectives: Japanese encephalitis (JE) is one of the commonest viral encephalitis especially prevalent in Southeast Asia. Estimated mortality rate of JE is ∼30%, with survivors undergoing severe and irreversible neurological sequelae. Although central nervous system (CNS) inflammation is imminent up...

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Bibliographic Details
Published in:Neurological research (New York) 2006-03, Vol.28 (2), p.190-192
Main Authors: Babu, G. Nagesh, Kalita, Jayantee, Misra, U. K.
Format: Article
Language:English
Subjects:
Biomarkers - blood
Biomarkers - cerebrospinal fluid
Brain - immunology
Brain - physiopathology
CYTOKINES
Cytokines - blood
Cytokines - cerebrospinal fluid
Encephalitis, Japanese - blood
Encephalitis, Japanese - cerebrospinal fluid
Encephalitis, Japanese - diagnosis
Humans
INTERLEUKIN-2
Interleukin-2 - cerebrospinal fluid
JAPANESE ENCEPHALITIS
NEUROINFLAMMATION
Predictive Value of Tests
TUMOR NECROSIS FACTOR-ALPHA
Tumor Necrosis Factor-alpha - cerebrospinal fluid
Up-Regulation - immunology
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Summary:Objectives: Japanese encephalitis (JE) is one of the commonest viral encephalitis especially prevalent in Southeast Asia. Estimated mortality rate of JE is ∼30%, with survivors undergoing severe and irreversible neurological sequelae. Although central nervous system (CNS) inflammation is imminent upon JE infection, the pathways underlying the same have not yet been clearly elucidated. However, cytokines-tumor necrosis factor-α (TNF-α) and interlukin-2 (IL-2), are small secreted proteins, which mediate and regulate immunity. Therefore, we wanted to evaluate the role, if any, of these cytokines in the pathogenesis of JE. Methods: We measured the levels of TNF-α and IL-2 in the serum and cerebrospinal fluid (CSF) of patients suffering JE, using enzyme-linked immunosorbent assay (ELISA). Results: JE infection caused a remarkable increase (p
ISSN:0161-6412
1743-1328
DOI:10.1179/016164106X98062