Inflammatory markers in the patients of Japanese encephalitis

Objectives: Japanese encephalitis (JE) is one of the commonest viral encephalitis especially prevalent in Southeast Asia. Estimated mortality rate of JE is ∼30%, with survivors undergoing severe and irreversible neurological sequelae. Although central nervous system (CNS) inflammation is imminent up...

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Published in:Neurological research (New York) 2006-03, Vol.28 (2), p.190-192
Main Authors: Babu, G. Nagesh, Kalita, Jayantee, Misra, U. K.
Format: Article
Language:English
Subjects:
Biomarkers - blood
Biomarkers - cerebrospinal fluid
Brain - immunology
Brain - physiopathology
CYTOKINES
Cytokines - blood
Cytokines - cerebrospinal fluid
Encephalitis, Japanese - blood
Encephalitis, Japanese - cerebrospinal fluid
Encephalitis, Japanese - diagnosis
Humans
INTERLEUKIN-2
Interleukin-2 - cerebrospinal fluid
JAPANESE ENCEPHALITIS
NEUROINFLAMMATION
Predictive Value of Tests
TUMOR NECROSIS FACTOR-ALPHA
Tumor Necrosis Factor-alpha - cerebrospinal fluid
Up-Regulation - immunology
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creator Babu, G. Nagesh
Kalita, Jayantee
Misra, U. K.
description Objectives: Japanese encephalitis (JE) is one of the commonest viral encephalitis especially prevalent in Southeast Asia. Estimated mortality rate of JE is ∼30%, with survivors undergoing severe and irreversible neurological sequelae. Although central nervous system (CNS) inflammation is imminent upon JE infection, the pathways underlying the same have not yet been clearly elucidated. However, cytokines-tumor necrosis factor-α (TNF-α) and interlukin-2 (IL-2), are small secreted proteins, which mediate and regulate immunity. Therefore, we wanted to evaluate the role, if any, of these cytokines in the pathogenesis of JE. Methods: We measured the levels of TNF-α and IL-2 in the serum and cerebrospinal fluid (CSF) of patients suffering JE, using enzyme-linked immunosorbent assay (ELISA). Results: JE infection caused a remarkable increase (p
doi_str_mv 10.1179/016164106X98062
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Results: JE infection caused a remarkable increase (p&lt;0.0001) in the levels of TNF-α in the serum and CSF, while IL-2 levels were unaffected. 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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Biomarkers - blood
Biomarkers - cerebrospinal fluid
Brain - immunology
Brain - physiopathology
CYTOKINES
Cytokines - blood
Cytokines - cerebrospinal fluid
Encephalitis, Japanese - blood
Encephalitis, Japanese - cerebrospinal fluid
Encephalitis, Japanese - diagnosis
Humans
INTERLEUKIN-2
Interleukin-2 - cerebrospinal fluid
JAPANESE ENCEPHALITIS
NEUROINFLAMMATION
Predictive Value of Tests
TUMOR NECROSIS FACTOR-ALPHA
Tumor Necrosis Factor-alpha - cerebrospinal fluid
Up-Regulation - immunology
title Inflammatory markers in the patients of Japanese encephalitis
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