Outcomes of Surgical Ligation after Unsuccessful Pharmacotherapy for Patent Ductus Arteriosus in Neonates Born Extremely Preterm

A retrospective cohort study of neonates born extremely preterm with persistent patent ductus arteriosus after unsuccessful pharmacologic closure compared outcomes between 166 surgically ligated and 142 nonligated neonates. After adjustment for confounders, ligation was not associated with the compo...

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Bibliographic Details
Published in:The Journal of pediatrics 2018-04, Vol.195, p.292-296.e3
Main Authors: Weisz, Dany E., Mirea, Lucia, Resende, Maura H.F., Ly, Linh, Church, Paige T., Kelly, Edmond, Kim, S. Joseph, Jain, Amish, McNamara, Patrick J., Shah, Prakesh S.
Format: Article
Language:English
Subjects:
cerebral palsy
chronic lung disease
confounding by indication
mortality
neurosensory impairment
nonsteroidal anti-inflammatory drug
PDA
retinopathy of prematurity
selection bias
survival bias
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Summary:A retrospective cohort study of neonates born extremely preterm with persistent patent ductus arteriosus after unsuccessful pharmacologic closure compared outcomes between 166 surgically ligated and 142 nonligated neonates. After adjustment for confounders, ligation was not associated with the composite outcome of death or neurodevelopmental impairment, neurodevelopmental impairment alone, chronic lung disease, or retinopathy of prematurity among survivors.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2017.11.029