Evaluation of Cognition and Cortical Excitability in Huntington’s Disease

Background: Recent advances in neurophysiological techniques have contributed to our understanding of the pathophysiology of Huntington’s disease (HD). Studies of the motor cortical excitability and central motor pathways have shown variable results. Objectives: Our aims were to evaluate the cortica...

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Bibliographic Details
Published in:Canadian journal of neurological sciences 2018-03, Vol.45 (2), p.176-181
Main Authors: Kamble, Nitish, Netravathi, M., Nagaraju, B.C., Lenka, Abhishek, Kumar, Keshav, Sowmya, V., Jain, Sanjeev, Pal, Pramod Kumar
Format: Article
Language:English
Subjects:
Adult
Animal cognition
Case-Control Studies
Cerebral Cortex - physiopathology
Cognition Disorders - etiology
Cognitive ability
Correlation of Data
Electromyography
Executive Function
Female
Humans
Huntington Disease - complications
Huntington Disease - pathology
Huntington Disease - therapy
Huntingtons disease
Male
Memory
Middle Aged
Neural Inhibition - physiology
Neuropsychological Tests
Neuropsychology
Original Articles
Statistical analysis
Transcranial Magnetic Stimulation
Treatment Outcome
Verbal Learning
Visual Perception
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Summary:Background: Recent advances in neurophysiological techniques have contributed to our understanding of the pathophysiology of Huntington’s disease (HD). Studies of the motor cortical excitability and central motor pathways have shown variable results. Objectives: Our aims were to evaluate the cortical excitability changes in HD using transcranial magnetic stimulation (TMS) and correlate the changes with cognitive impairment. Methods: The study included 32 HD patients and 30 age- and gender-matched controls. The demographic and clinical profiles of the patients were recorded. All subjects were evaluated by TMS and resting motor threshold (RMT), central motor conduction time (CMCT), silent period (SP), short-interval intracortical inhibition (SICI), and intracortical facilitation were determined. A battery of neuropsychological tests was administered to all subjects. Results: The mean age of the patients was 42.1±14.1 years, and that of controls 39.4±12.4 years (p=0.61). There was no significant difference in RMT and CMCT between the two groups. There was a mild prolongation of the contralateral SP in HD, but it was not significant. SICI was significantly reduced in HD (p
ISSN:0317-1671
2057-0155
DOI:10.1017/cjn.2017.277