Image-guided Ommaya reservoir insertion for intraventricular chemotherapy: a retrospective series

• Published in: Acta neurochirurgica 2018-03, Vol.160 (3), p.539-544
• Main Authors: Lau, Jonathan C., Kosteniuk, Suzanne E., Macdonald, David R., Megyesi, Joseph F.
• Format: Article
• Language: English
• Subjects: Acute lymphoblastic leukemia; B-cell lymphoma; Catheters; Cerebrospinal fluid; Chemotherapy; Complications; Demographics; Historical account; Immunoglobulins; Insertion; Interventional Radiology; Leukemia; Lymphatic leukemia; Lymphocytes B; Lymphoma; Medical instruments; Medicine; Medicine & Public Health; Meninges; Minimally Invasive Surgery; Morbidity; Neurology; Neuroradiology; Neurosurgery; Original Article - Brain Tumors; Surgical Orthopedics
• ISSN: 0001-6268; 0942-0940
• DOI: 10.1007/s00701-017-3454-z

Background Ayub Ommaya proposed a surgical technique for subcutaneous reservoir and pump placement in 1963 to allow access to intraventricular cerebrospinal fluid (CSF). Currently, the most common indication for Ommaya reservoir insertion (ORI) in adults is for patients with hematologic or leptomeningeal disorders requiring repeated injection of chemotherapy into the CSF space. Historically, the intraventricular catheter has been inserted blindly based on anatomical landmarks. The purpose of this study was to examine short-term complication rates with ORI with image guidance (IG) and without image guidance (non-IG). Methods We retrospectively evaluated all operative cases of ORI from 2000 to 2014 by the senior author. Patient demographic data, surgical outcomes, and peri-operative complications were collected. Accurate placement and early (30-day) morbidity or mortality were considered primary outcomes. Results Fifty-five consecutive patients underwent ORI by the senior author over the study period (43.5 ± 16.6 years; 40.0% female). Indications for placement included acute lymphoblastic leukemia, diffuse large B-cell lymphoma, and leptomeningeal carcinomatosis. There were seven (12.7%) total complications: three (37.5%) with no-IG versus four (8.5%) with IG. Catheter malpositions were significantly higher in the non-IG group at 37.5% compared to 2.1%. Catheters were also more likely to require multiple passes with non-IG at 25% compare to 0% with IG. There were no early infections in either group. Conclusions We demonstrate improved accuracy and decreased complications using an image-guided approach compared with a traditional approach. Our results support routine use of intra-operative image guidance for proximal catheter insertion in elective ORI for intraventricular chemotherapy.