Particular Role of JAK/STAT3 Signaling in Functional Control of Mesenchymal Progenitor Cells

The role of JAK/STAT3-mediated signaling pathway in the realization of the growth potential of mesenchymal precursor cells was examined in vitro . The stimulating role of JAKs and STAT3 towards proliferating activity of progenitor cells and their different role in the regulation of differentiation o...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-01, Vol.164 (3), p.316-319
Main Authors: Zyuz’kov, G. N., Udut, E. V., Miroshnichenko, L. A., Polyakova, T. Yu, Simanina, E. V., Stavrova, L. A., Chaikovskii, A. V., Agafonov, V. I., Borodulina, E. V., Timofeev, M. S., Zyuz’kova, Yu. N., Danilets, M. G., Zhdanov, V. V., Udut, V. V.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cellular signal transduction
Internal Medicine
Laboratory Medicine
Mesenchyme
Pathology
Progenitor cells
Signal transduction
Stat3 protein
Stem cells
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Summary:The role of JAK/STAT3-mediated signaling pathway in the realization of the growth potential of mesenchymal precursor cells was examined in vitro . The stimulating role of JAKs and STAT3 towards proliferating activity of progenitor cells and their different role in the regulation of differentiation of the progenitor elements were demonstrated. Inhibitors of JAKs and STAT3 reduced the yield of fibroblast CFU and their mitotic activity. Blockade of JAKs accelerated and selective inactivation of STAT3 decelerated differentiation of progenitor cells.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-3980-6