Left Ventricular Mass Influences Relationship Between Filling Pressure and Early-Diastolic Ratio of Inflow Velocity to Mitral Annular Velocity (E/e′)

• Published in: Circulation Journal 2018/02/23, Vol.82(3), pp.732-738
• Main Authors: Nakabachi, Masahiro, Yamada, Satoshi, Iwano, Hiroyuki, Hayashi, Taichi, Okada, Kazunori, Kusunose, Kenya, Watanabe, Kiyotaka, Ishizu, Tomoko, Wakami, Kazuaki, Yamada, Hirotsugu, Dohi, Kaoru, Seo, Yoshihiro, Ohte, Nobuyuki, Shimizu, Chikara, Mikami, Taisei
• Format: Article
• Language: English
• Subjects: Aged; Blood Flow Velocity; Cardiac Catheterization - methods; Diastolic function; Echocardiography; Female; Humans; Hypertension - physiopathology; Left ventricular filling pressure; Left ventricular hypertrophy; Male; Middle Aged; Models, Cardiovascular; Stroke Volume; Tissue Doppler; Ventricular Dysfunction, Left; Ventricular Function, Left - physiology; Ventricular Pressure - physiology
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-17-1019

Background:Early-diastolic mitral annular velocity (e′) and the ratio of early-diastolic left ventricular (LV) inflow velocity (E) to e′ (E/e′) have been widely used as indexes of LV relaxation and filling pressure, respectively. However, many recent studies have demonstrated that they are not reliable in various clinical settings. We thus investigated the factors influencing these echocardiographic parameters in a multicenter study.Methods and Results:The study group comprised 69 patients, referred for cardiac catheterization, and enrolled in 5 university hospitals. Time constant (τ) and LV mean diastolic pressure (LVMDP) were measured using a micromanometer-tipped catheter. Although e′ only weakly correlated with τ (r=−0.35, P