Mimetic Ag nanoparticle/Zn-based MOF nanocomposite (AgNPs@ZnMOF) capped with molecularly imprinted polymer for the selective detection of patulin

• Published in: Talanta (Oxford) 2018-03, Vol.179, p.710-718
• Main Authors: Bagheri, Nafiseh, Khataee, Alireza, Habibi, Biuck, Hassanzadeh, Javad
• Format: Article
• Language: English
• Subjects: Ag nanoparticles; Biomimetic Materials - chemistry; Catalysis; Hydrogen Peroxide - chemistry; Limit of Detection; Metal Nanoparticles - chemistry; Metal Nanoparticles - ultrastructure; MOF nanocomposites; Molecular Imprinting - methods; Mutagens - analysis; Nanocomposites - chemistry; Nanocomposites - ultrastructure; Patulin; Patulin - analysis; Peroxidase - chemistry; Peroxidase-like activity; Phthalic Acids - chemistry; Propylamines - chemistry; Silanes - chemistry; Silver - chemistry; Spectrometry, Fluorescence - methods; Zinc - chemistry
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2017.12.009

Here, Ag nanoparticle/flake-like Zn-based MOF nanocomposite (AgNPs@ZnMOF) with great peroxidase-like activity was applied as an efficient support for molecularly imprinted polymer (MIP) and successfully used for selective determination of patulin. AgNPs@ZnMOF was simply synthesized by creating Ag nanoparticles (Ag NPs) inside the nano-pores of flake-like (Zn)MOF. The high surface area of MOF remarkably improved the catalytic activity of Ag NPs which was assessed by fluorometric, colorimetric and electrochemical techniques. Furthermore, it was observed that patulin could strangely reduce the catalytic activity of AgNPs@ZnMOF, probably due to its electron capturing features. This outcome was the motivation to design an assay for patulin detection. In order to make a selective interaction with patulin molecules, MIP layer was created on the surface of AgNPs@ZnMOF by co-polymerization reaction of 3-aminopropyl triethoxysilane (APTES) and tetraethyl orthosilicate (TEOS) monomers wherein patulin was applied as template agent. Combination between the selective identifying feature of MIP and outstanding peroxidase-like activity of novel AgNPs@ZnMOF nanocomposite as well as the sensitive fluorescence detection system was led to the design of a reliable probe for patulin. The prepared MIP-capped AgNPs@ZnMOF catalyzed the H2O2-terephthalic acid reaction which produced a high florescent product. In the presence of patulin, the fluorescence intensity was decreased proportional to its concentration in the range of 0.1–10µmolL−1 with a detection limit of 0.06µmolL−1. The proposed method was able to selectively measure patulin in a complex media without significant interfering effects from analogue compounds. Ag nanoparticles/flake-like (Zn)MOF nanocomposite was synthesized as a novel peroxidase-like catalyst. Based on inhibition effect of patulin on this activity, a sensitive fluorometric probe was designed for its detection. Selectivity was controlled by surface imprinting technique. [Display omitted] •Synthesis of Ag nanoparticle/flake-like Zn-based MOF nanocomposite (AgNPs@MOF).•Great improvement effect of MOF on mimetic activity of encapsulated Ag nanoparticle.•Fluorometric, colorimetric and electrochemical study of AgNPs@MOF mimetic activity.•Preparation of molecularly imprinted polymer (MIP) on AgNPs@MOF.•Selective fluorometric detection of patulin by MIP-capped AgNPs@MOF.