The predictive value and role of stromal tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma (PDAC)

Recently, increasing evidence has indicated that the presence of tumor infiltrating immune cells has shown predictive significance for many solid tumors. Present study was performed to evaluate the predictive value of stromal tumor-infiltrating lymphocytes (TILs) for the presence of liver metastasis...

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Bibliographic Details
Published in:Cancer biology & therapy 2018-04, Vol.19 (4), p.296-305
Main Authors: Lianyuan, Tao, Dianrong, Xiu, Chunhui, Yuan, Zhaolai, Ma, Bin, Jiang
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Carcinoma, Pancreatic Ductal - diagnosis
Carcinoma, Pancreatic Ductal - mortality
Carcinoma, Pancreatic Ductal - secondary
Carcinoma, Pancreatic Ductal - surgery
Cell Line, Tumor
Coculture Techniques
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Liver Neoplasms - diagnosis
Liver Neoplasms - mortality
Liver Neoplasms - secondary
Lymphocytes, Tumor-Infiltrating
Male
Middle Aged
Pancreas - pathology
Pancreas - surgery
Pancreatectomy
pancreatic ductal adenocarcinoma
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Predictive Value of Tests
Primary Cell Culture
Prognosis
prognosis, TNF-alpha
Research Papers
Tumor Necrosis Factor-alpha - metabolism
tumor-infiltrating lymphocytes
Young Adult
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Summary:Recently, increasing evidence has indicated that the presence of tumor infiltrating immune cells has shown predictive significance for many solid tumors. Present study was performed to evaluate the predictive value of stromal tumor-infiltrating lymphocytes (TILs) for the presence of liver metastasis and overall survival in PDAC (pancreatic ductal adenocarcinoma) patients after complete resection and to explore the potential role of lymphocytes in PDAC. A total of 155 resectable patients with PDAC were enrolled in our study. Stromal TIL density was investigated in hematoxylin and eosin-stained sections of surgical specimens and scored. The effect and possible mechanism of lymphocytes on cancer cells was evaluated using co-culture techniques and ELISA test. Stromal TIL negative status (HR = 2.80, 95% CI 1.75-4.48, P < 0.01) was not only an independent predictor of worse OS (HR = 2.7, 95% CI 1.80-4.06, P =
ISSN:1538-4047
1555-8576
DOI:10.1080/15384047.2017.1416932