A case of paraneoplastic neuromyelitis optica associated with small cell lung carcinoma

Neuromyelitis optic spectrum disorders are demyelinating conditions that are typically idiopathic, though various case reports have demonstrated an association with malignancy. We present the case of a 64year old woman with NMOSD in the setting of small cell lung cancer. She had longitudinally exten...

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Bibliographic Details
Published in:Journal of neuroimmunology 2018-03, Vol.316, p.130-132
Main Authors: Deuel, Lisa M., Bunch, Marjorie E.
Format: Article
Language:English
Subjects:
Neuromyelitis optica spectrum disorders
Optic neuritis
Paraneoplastic conditions
Small cell lung cancer
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Summary:Neuromyelitis optic spectrum disorders are demyelinating conditions that are typically idiopathic, though various case reports have demonstrated an association with malignancy. We present the case of a 64year old woman with NMOSD in the setting of small cell lung cancer. She had longitudinally extensive transverse myelitis and left eye optic neuritis; aquaporin-4 antibodies were elevated. Biopsy of mediastinal adenopathy was positive for SCLC. Malignancy should be considered in any patient with an atypical presentation of NMOSD, or who does not respond to traditional therapies. [Display omitted] •Neuromyelitis optic spectrum disorders have been linked to multiple neoplasms as paraneoplastic conditions.•Small cell lung cancer is the most common malignancy associated with paraneoplastic conditions of any kind.•NMOSD have never before been described in the setting of SCLC.•Consider malignancy in any patient presenting with atypical age at onset or unresponsiveness to immunosuppressive therapy.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2018.01.003