DNA damage in rats with streptozotocin-induced diabetes; protective effect of silibinin

Silibinin, the active component of Silybum marianum (L.), is a powerful antioxidant. Male rats with streptozotocin-induced diabetes were treated with silibinin. DNA damage was demonstrated by the comet assay in the control, diabetic, and treatment groups. DNA damage was increased in diabetic rats an...

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Bibliographic Details
Published in:Mutation research. Genetic toxicology and environmental mutagenesis 2018-01, Vol.825, p.15-18
Main Authors: Toğay, Vehbi Atahan, Sevimli, Tuğba Semerci, Sevimli, Murat, Çelik, Dilek Aşcı, Özçelik, Nurten
Format: Article
Language:English
Subjects:
Comet assay
Silmarin
Silybum marianum
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Summary:Silibinin, the active component of Silybum marianum (L.), is a powerful antioxidant. Male rats with streptozotocin-induced diabetes were treated with silibinin. DNA damage was demonstrated by the comet assay in the control, diabetic, and treatment groups. DNA damage was increased in diabetic rats and decreased by silibinin treatment.
ISSN:1383-5718
1879-3592
DOI:10.1016/j.mrgentox.2017.11.002