Hydrogel implant is as effective as osteochondral autologous transplantation for treating focal cartilage knee injury in 24 months

Purpose The treatment approach for a patient with knee joint focal cartilage lesion is a difficult decision. To date, there has been no randomized clinical trial involving Hydrogel (Cartiva™). This study evaluated and compared the results of a hydrogel implant (Cartiva™) with autologous osteochondra...

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Bibliographic Details
Published in:Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA sports traumatology, arthroscopy : official journal of the ESSKA, 2018-10, Vol.26 (10), p.2934-2941
Main Authors: de Queiroz, Antonio Altenor Bessa, Debieux, Pedro, Amaro, Joicemar, Ferretti, Mario, Cohen, Moises
Format: Article
Language:English
Subjects:
Activities of Daily Living
Adult
Autografts
Biocompatibility
Bone implants
Bone Transplantation
Cartilage
Cartilage, Articular - surgery
Complications
Female
Humans
Hydrogels
Knee
Knee Injuries - surgery
Knee Joint - surgery
Lesions
Male
Medicine
Medicine & Public Health
Middle Aged
Orthopedics
Pain
Pain Measurement
Patients
Prostheses and Implants
Quality of Life
Surgery
Transplantation
Transplantation, Autologous
Transplants & implants
Treatment Outcome
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Summary:Purpose The treatment approach for a patient with knee joint focal cartilage lesion is a difficult decision. To date, there has been no randomized clinical trial involving Hydrogel (Cartiva™). This study evaluated and compared the results of a hydrogel implant (Cartiva™) with autologous osteochondral transplantation (AOT) for treating knee joint focal cartilage lesions. Methods Thirty-eight symptomatic patients, with a focal cartilage lesion of Outerbridge grades III or IV, were randomized into one of two groups according to the inclusion and exclusion criteria. Group I underwent AOT, and Group II was treated with a Hydrogel implant. Patients were evaluated preoperatively and again postoperatively at 6, 12, and 24 months using the subjective International Knee Documentation Committee (IKDC) scores, Visual Analog Scale for Pain (VAS Pain), Activities of Daily Living Scale (ADLS) and Lysholm score. Results Both groups showed significant improvements from baseline (pre-surgery) to post-surgery (6, 12, and 24 months; p  
ISSN:0942-2056
1433-7347
DOI:10.1007/s00167-018-4834-5