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Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study
Atherosclerosis, a chronic inflammatory disease in arterial blood vessels, is one of the major causes of death in worldwide. Meanwhile, periodontal disease is a chronic inflammatory disease caused by infection with periodontal pathogens such as P. gingivalis ( Porphyromonas gingivalis ). Several stu...
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| Published in: | Odontology 2018-07, Vol.106 (3), p.316-327 |
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| creator | Kudo, Chieko Shin, Wee Soo Sasaki, Nobuhiro Harai, Kazuo Kato, Kai Seino, Hiroaki Goke, Eiji Fujino, Takemasa Kuribayashi, Nobuichi Pearce, Youko Onuki Taira, Masato Matsushima, Ryoji Minabe, Masato Takashiba, Shogo |
| description | Atherosclerosis, a chronic inflammatory disease in arterial blood vessels, is one of the major causes of death in worldwide. Meanwhile, periodontal disease is a chronic inflammatory disease caused by infection with periodontal pathogens such as
P. gingivalis
(
Porphyromonas gingivalis
). Several studies have reported association between periodontal infection and atherosclerosis, but direct investigation about the effects of periodontal treatment on atherosclerosis has not been reported. We have planned Japanese local clinics to determine the relationship between periodontal disease and atherosclerosis under collaborative with medical and dental care. A prospective, multicentre, observational study was conducted including 38 medical patients with lifestyle-related diseases in the stable period under consultation at participating medical clinics and 92 periodontal patients not undergoing medical treatment but who were consulting at participating dental clinics. Systemic and periodontal examinations were performed before and after periodontal treatment. At baseline, LDL-C (low-density lipoprotein cholesterol) levels and percentage (%) of mobile teeth were positively related to plasma IgG (immunoglobulin) antibody titer against
P. gingivalis
with multivariate analysis. Corresponding to improvements in periodontal clinical parameters after treatment, right and left max IMT (maximum intima-media thickness) levels were decreased significantly after treatment (SPT-S: start of supportive periodontal therapy, SPT-1y: at 1 year under SPT, and SPT-3y: at 3 years under SPT). The present study has clarified our previous univariate analysis results, wherein
P. gingivalis
infection was positively associated with progression of atherosclerosis. Thus, routine screening using plasma IgG antibody titer against
P. gingivalis
and periodontal treatment under collaborative with medical and dental care may prevent cardiovascular accidents caused by atherosclerosis. |
| doi_str_mv | 10.1007/s10266-017-0331-4 |
| format | article |
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P. gingivalis
(
Porphyromonas gingivalis
). Several studies have reported association between periodontal infection and atherosclerosis, but direct investigation about the effects of periodontal treatment on atherosclerosis has not been reported. We have planned Japanese local clinics to determine the relationship between periodontal disease and atherosclerosis under collaborative with medical and dental care. A prospective, multicentre, observational study was conducted including 38 medical patients with lifestyle-related diseases in the stable period under consultation at participating medical clinics and 92 periodontal patients not undergoing medical treatment but who were consulting at participating dental clinics. Systemic and periodontal examinations were performed before and after periodontal treatment. At baseline, LDL-C (low-density lipoprotein cholesterol) levels and percentage (%) of mobile teeth were positively related to plasma IgG (immunoglobulin) antibody titer against
P. gingivalis
with multivariate analysis. Corresponding to improvements in periodontal clinical parameters after treatment, right and left max IMT (maximum intima-media thickness) levels were decreased significantly after treatment (SPT-S: start of supportive periodontal therapy, SPT-1y: at 1 year under SPT, and SPT-3y: at 3 years under SPT). The present study has clarified our previous univariate analysis results, wherein
P. gingivalis
infection was positively associated with progression of atherosclerosis. Thus, routine screening using plasma IgG antibody titer against
P. gingivalis
and periodontal treatment under collaborative with medical and dental care may prevent cardiovascular accidents caused by atherosclerosis.</description><identifier>ISSN: 1618-1247</identifier><identifier>EISSN: 1618-1255</identifier><identifier>DOI: 10.1007/s10266-017-0331-4</identifier><identifier>PMID: 29330707</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - diagnosis ; Atherosclerosis - microbiology ; Biomarkers - analysis ; Blood vessels ; Carotid Intima-Media Thickness ; Cholesterol ; Chronic infection ; Dental care ; Dentistry ; Diagnostic Imaging ; Disease Progression ; Female ; Gum disease ; Humans ; Immunoglobulin G ; Infections ; Inflammatory diseases ; Japan ; Life Style ; Low density lipoprotein ; Male ; Medicine ; Middle Aged ; Multivariate analysis ; Observational studies ; Oral and Maxillofacial Surgery ; Original Article ; Patients ; Periodontal Diseases - diagnosis ; Periodontal Diseases - microbiology ; Periodontal Diseases - therapy ; Periodontics ; Porphyromonas gingivalis - pathogenicity ; Prospective Studies ; Teeth</subject><ispartof>Odontology, 2018-07, Vol.106 (3), p.316-327</ispartof><rights>The Society of The Nippon Dental University 2018</rights><rights>Odontology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-d42b12ee42221d1f38825bf13165228db98fcdeb864efda30353e26b6afd51e63</citedby><cites>FETCH-LOGICAL-c396t-d42b12ee42221d1f38825bf13165228db98fcdeb864efda30353e26b6afd51e63</cites><orcidid>0000-0002-2621-4803</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29330707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kudo, Chieko</creatorcontrib><creatorcontrib>Shin, Wee Soo</creatorcontrib><creatorcontrib>Sasaki, Nobuhiro</creatorcontrib><creatorcontrib>Harai, Kazuo</creatorcontrib><creatorcontrib>Kato, Kai</creatorcontrib><creatorcontrib>Seino, Hiroaki</creatorcontrib><creatorcontrib>Goke, Eiji</creatorcontrib><creatorcontrib>Fujino, Takemasa</creatorcontrib><creatorcontrib>Kuribayashi, Nobuichi</creatorcontrib><creatorcontrib>Pearce, Youko Onuki</creatorcontrib><creatorcontrib>Taira, Masato</creatorcontrib><creatorcontrib>Matsushima, Ryoji</creatorcontrib><creatorcontrib>Minabe, Masato</creatorcontrib><creatorcontrib>Takashiba, Shogo</creatorcontrib><creatorcontrib>Periodontitis and Atherosclerosis Project-Tokyo and Chiba Consortiums</creatorcontrib><creatorcontrib>Periodontitis and Atherosclerosis Project-Tokyo and Chiba Consortiums</creatorcontrib><title>Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study</title><title>Odontology</title><addtitle>Odontology</addtitle><addtitle>Odontology</addtitle><description>Atherosclerosis, a chronic inflammatory disease in arterial blood vessels, is one of the major causes of death in worldwide. Meanwhile, periodontal disease is a chronic inflammatory disease caused by infection with periodontal pathogens such as
P. gingivalis
(
Porphyromonas gingivalis
). Several studies have reported association between periodontal infection and atherosclerosis, but direct investigation about the effects of periodontal treatment on atherosclerosis has not been reported. We have planned Japanese local clinics to determine the relationship between periodontal disease and atherosclerosis under collaborative with medical and dental care. A prospective, multicentre, observational study was conducted including 38 medical patients with lifestyle-related diseases in the stable period under consultation at participating medical clinics and 92 periodontal patients not undergoing medical treatment but who were consulting at participating dental clinics. Systemic and periodontal examinations were performed before and after periodontal treatment. At baseline, LDL-C (low-density lipoprotein cholesterol) levels and percentage (%) of mobile teeth were positively related to plasma IgG (immunoglobulin) antibody titer against
P. gingivalis
with multivariate analysis. Corresponding to improvements in periodontal clinical parameters after treatment, right and left max IMT (maximum intima-media thickness) levels were decreased significantly after treatment (SPT-S: start of supportive periodontal therapy, SPT-1y: at 1 year under SPT, and SPT-3y: at 3 years under SPT). The present study has clarified our previous univariate analysis results, wherein
P. gingivalis
infection was positively associated with progression of atherosclerosis. Thus, routine screening using plasma IgG antibody titer against
P. gingivalis
and periodontal treatment under collaborative with medical and dental care may prevent cardiovascular accidents caused by atherosclerosis.</description><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - diagnosis</subject><subject>Atherosclerosis - microbiology</subject><subject>Biomarkers - analysis</subject><subject>Blood vessels</subject><subject>Carotid Intima-Media Thickness</subject><subject>Cholesterol</subject><subject>Chronic infection</subject><subject>Dental care</subject><subject>Dentistry</subject><subject>Diagnostic Imaging</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Infections</subject><subject>Inflammatory diseases</subject><subject>Japan</subject><subject>Life Style</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Observational studies</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Original Article</subject><subject>Patients</subject><subject>Periodontal Diseases - diagnosis</subject><subject>Periodontal Diseases - microbiology</subject><subject>Periodontal Diseases - therapy</subject><subject>Periodontics</subject><subject>Porphyromonas gingivalis - pathogenicity</subject><subject>Prospective Studies</subject><subject>Teeth</subject><issn>1618-1247</issn><issn>1618-1255</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1TAQhS0EoqXwAGyQJTZsTP2TOAk7VJU_VWLTriMnHlOXJA4ep9V9Hx6UubqlQkhd2bK_OXNmDmOvlXyvpGxOUUltrZCqEdIYJaon7FhZ1Qql6_rpw71qjtgLxBspdVMZ-Zwd6c4Y2cjmmP0-DwHGgjwFvkKOyaeluImXDK7MsBSeFj66nEr0PC4lzk7M4KPj5TqOPxdApGe-uhIJRn4XyzWfYgAsuwlEhskV8NxHBIeAH_g3tzqqAr7mhCu1jrfA520qcSSBDDwNCPmW9NJCPrBsfveSPQtuQnh1f56wq0_nl2dfxMX3z1_PPl6I0XS2CF_pQWmASmutvAqmbXU9BGWUrbVu_dC1YfQwtLaC4J2Rpjag7WBd8LUCa07Yu4Muefu10Qj9HHGEaSLHacNedW1XN21jO0Lf_ofepC2T4z3V6aarW1URpQ7USMNihtCvmTaYd72S_T7C_hBhTxH2-wj7fc2be-VtoE0_VPzNjAB9AJC-lh-Q_2n9qOofzHSrGg</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Kudo, Chieko</creator><creator>Shin, Wee Soo</creator><creator>Sasaki, Nobuhiro</creator><creator>Harai, Kazuo</creator><creator>Kato, Kai</creator><creator>Seino, Hiroaki</creator><creator>Goke, Eiji</creator><creator>Fujino, Takemasa</creator><creator>Kuribayashi, Nobuichi</creator><creator>Pearce, Youko Onuki</creator><creator>Taira, Masato</creator><creator>Matsushima, Ryoji</creator><creator>Minabe, Masato</creator><creator>Takashiba, Shogo</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2621-4803</orcidid></search><sort><creationdate>20180701</creationdate><title>Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study</title><author>Kudo, Chieko ; Shin, Wee Soo ; Sasaki, Nobuhiro ; Harai, Kazuo ; Kato, Kai ; Seino, Hiroaki ; Goke, Eiji ; Fujino, Takemasa ; Kuribayashi, Nobuichi ; Pearce, Youko Onuki ; Taira, Masato ; Matsushima, Ryoji ; Minabe, Masato ; Takashiba, Shogo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-d42b12ee42221d1f38825bf13165228db98fcdeb864efda30353e26b6afd51e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - 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Academic</collection><jtitle>Odontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kudo, Chieko</au><au>Shin, Wee Soo</au><au>Sasaki, Nobuhiro</au><au>Harai, Kazuo</au><au>Kato, Kai</au><au>Seino, Hiroaki</au><au>Goke, Eiji</au><au>Fujino, Takemasa</au><au>Kuribayashi, Nobuichi</au><au>Pearce, Youko Onuki</au><au>Taira, Masato</au><au>Matsushima, Ryoji</au><au>Minabe, Masato</au><au>Takashiba, Shogo</au><aucorp>Periodontitis and Atherosclerosis Project-Tokyo and Chiba Consortiums</aucorp><aucorp>Periodontitis and Atherosclerosis Project-Tokyo and Chiba Consortiums</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study</atitle><jtitle>Odontology</jtitle><stitle>Odontology</stitle><addtitle>Odontology</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>106</volume><issue>3</issue><spage>316</spage><epage>327</epage><pages>316-327</pages><issn>1618-1247</issn><eissn>1618-1255</eissn><abstract>Atherosclerosis, a chronic inflammatory disease in arterial blood vessels, is one of the major causes of death in worldwide. Meanwhile, periodontal disease is a chronic inflammatory disease caused by infection with periodontal pathogens such as
P. gingivalis
(
Porphyromonas gingivalis
). Several studies have reported association between periodontal infection and atherosclerosis, but direct investigation about the effects of periodontal treatment on atherosclerosis has not been reported. We have planned Japanese local clinics to determine the relationship between periodontal disease and atherosclerosis under collaborative with medical and dental care. A prospective, multicentre, observational study was conducted including 38 medical patients with lifestyle-related diseases in the stable period under consultation at participating medical clinics and 92 periodontal patients not undergoing medical treatment but who were consulting at participating dental clinics. Systemic and periodontal examinations were performed before and after periodontal treatment. At baseline, LDL-C (low-density lipoprotein cholesterol) levels and percentage (%) of mobile teeth were positively related to plasma IgG (immunoglobulin) antibody titer against
P. gingivalis
with multivariate analysis. Corresponding to improvements in periodontal clinical parameters after treatment, right and left max IMT (maximum intima-media thickness) levels were decreased significantly after treatment (SPT-S: start of supportive periodontal therapy, SPT-1y: at 1 year under SPT, and SPT-3y: at 3 years under SPT). The present study has clarified our previous univariate analysis results, wherein
P. gingivalis
infection was positively associated with progression of atherosclerosis. Thus, routine screening using plasma IgG antibody titer against
P. gingivalis
and periodontal treatment under collaborative with medical and dental care may prevent cardiovascular accidents caused by atherosclerosis.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>29330707</pmid><doi>10.1007/s10266-017-0331-4</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-2621-4803</orcidid></addata></record> |
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| ispartof | Odontology, 2018-07, Vol.106 (3), p.316-327 |
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| language | eng |
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| source | Springer Link |
| subjects | Arteriosclerosis Atherosclerosis Atherosclerosis - diagnosis Atherosclerosis - microbiology Biomarkers - analysis Blood vessels Carotid Intima-Media Thickness Cholesterol Chronic infection Dental care Dentistry Diagnostic Imaging Disease Progression Female Gum disease Humans Immunoglobulin G Infections Inflammatory diseases Japan Life Style Low density lipoprotein Male Medicine Middle Aged Multivariate analysis Observational studies Oral and Maxillofacial Surgery Original Article Patients Periodontal Diseases - diagnosis Periodontal Diseases - microbiology Periodontal Diseases - therapy Periodontics Porphyromonas gingivalis - pathogenicity Prospective Studies Teeth |
| title | Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study |
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