Neural circuit dysfunction in mouse models of neurodevelopmental disorders

• Published in: Current opinion in neurobiology 2018-02, Vol.48, p.174-182
• Main Authors: del Pino, Isabel, Rico, Beatriz, Marín, Oscar
• Format: Article
• Language: English
• Subjects: Animals; Brain - pathology; Brain - physiopathology; Disease Models, Animal; Mice; Nerve Net - physiopathology; Neural Pathways - physiopathology; Neurodevelopmental Disorders - pathology
• ISSN: 0959-4388; 1873-6882
• DOI: 10.1016/j.conb.2017.12.013

•Dissecting circuit dysfunction sheds light on the etiology of neural disorders.•Early onset of neural circuit alterations in multiple mouse models.•Neural circuit alterations during development cause ‘domino effects’.•Early intervention during critical periods may rescue circuit deficits. Neuropsychiatric disorders arise from the alteration of normal brain developmental trajectories disrupting the function of specific neuronal circuits. Recent advances in human genetics have greatly accelerated the identification of genes whose variation increases the susceptibility for neurodevelopmental disorders, most notably for autism spectrum disorder (ASD) and schizophrenia. In parallel, experimental studies in animal models—most typically in mice—are beginning to shed light on the role of these genes in the development and function of specific brain circuits. In spite of their limitations, understanding the impact of pathological gene variation in animal models at the level of specific neuronal populations and circuits will likely contribute to orienting human clinical studies in the search for precise disease mechanisms and novel treatments.