Loading…

Novel Mortality Markers for Critically Ill Patients

Aim: Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess th...

Full description

Saved in:
Bibliographic Details
Published in:Journal of intensive care medicine 2020-04, Vol.35 (4), p.383-385
Main Authors: Yoldas, Hamit, Karagoz, Ibrahim, Ogun, Muhammed Nur, Velioglu, Yusuf, Yildiz, Isa, Bilgi, Murat, Demirhan, Abdullah
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c337t-25f565913fd726f40a3d022b34b7d55cd6c0b2e451e5528831900186de0e1a8b3
cites cdi_FETCH-LOGICAL-c337t-25f565913fd726f40a3d022b34b7d55cd6c0b2e451e5528831900186de0e1a8b3
container_end_page 385
container_issue 4
container_start_page 383
container_title Journal of intensive care medicine
container_volume 35
creator Yoldas, Hamit
Karagoz, Ibrahim
Ogun, Muhammed Nur
Velioglu, Yusuf
Yildiz, Isa
Bilgi, Murat
Demirhan, Abdullah
description Aim: Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess the usefulness of the NLR and PLR as markers of hospital stay and mortality of patients in intensive care units (ICUs). Methods: Patients treated in the ICU of our institution between October 2016 and August 2017 were enrolled in the study. After obtaining approval from the institutional committee, patient data were sourced from the institution’s computerized database and retrospectively analyzed. The patients were assigned to 2 groups according to the outcomes: survivors and deceased. Results: The NLR of survivors and deceased patients was 2.06 (1.18-21.68) and 10.42 (2.85-48.2), respectively. The NLR was significantly elevated in deceased patients as compared with that of survivors (P < .001). Similarly, the median PLR of patients in the deceased group (268.9 [150-3000]) was significantly higher than that of patients in the survivor group (55.7 [11.8-152.5]). The difference in the PLR between groups was significant (P < .001). Conclusion: Both the NLR and PLR, as well as C-reactive protein, predicted mortality in this critically ill population. The PLR and NLR are easy-to-measure, inexpensive markers. Physicians should be aware of elevations in PLR and NLR in patient care in ICUs.
doi_str_mv 10.1177/0885066617753389
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1989587964</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0885066617753389</sage_id><sourcerecordid>1989587964</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-25f565913fd726f40a3d022b34b7d55cd6c0b2e451e5528831900186de0e1a8b3</originalsourceid><addsrcrecordid>eNp1kL1PwzAQxS0EoqWwM6GMLAHbFzv2iCo-KrXAALPlJBeU4tbFdpD635OqwIDEdCe933u6e4ScM3rFWFleU6UElVIOuwBQ-oCMmeAiZ4XSh2S8k_OdPiInMS4pZcCBHZMR1wCFAj4m8Og_0WULH5J1XdpmCxveMcSs9SGbhi51tXVum82cy55t6nCd4ik5aq2LePY9J-T17vZl-pDPn-5n05t5XgOUKeeiFVJoBm1TctkW1EJDOa-gqMpGiLqRNa04FoKhEFwpYHq4UMkGKTKrKpiQy33uJviPHmMyqy7W6Jxdo--jYVppoUotiwGle7QOPsaArdmEbmXD1jBqdlWZv1UNlovv9L5aYfNr-OlmAPI9EO0bmqXvw3r49v_ALyxKboE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1989587964</pqid></control><display><type>article</type><title>Novel Mortality Markers for Critically Ill Patients</title><source>SAGE</source><creator>Yoldas, Hamit ; Karagoz, Ibrahim ; Ogun, Muhammed Nur ; Velioglu, Yusuf ; Yildiz, Isa ; Bilgi, Murat ; Demirhan, Abdullah</creator><creatorcontrib>Yoldas, Hamit ; Karagoz, Ibrahim ; Ogun, Muhammed Nur ; Velioglu, Yusuf ; Yildiz, Isa ; Bilgi, Murat ; Demirhan, Abdullah</creatorcontrib><description>Aim: Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess the usefulness of the NLR and PLR as markers of hospital stay and mortality of patients in intensive care units (ICUs). Methods: Patients treated in the ICU of our institution between October 2016 and August 2017 were enrolled in the study. After obtaining approval from the institutional committee, patient data were sourced from the institution’s computerized database and retrospectively analyzed. The patients were assigned to 2 groups according to the outcomes: survivors and deceased. Results: The NLR of survivors and deceased patients was 2.06 (1.18-21.68) and 10.42 (2.85-48.2), respectively. The NLR was significantly elevated in deceased patients as compared with that of survivors (P &lt; .001). Similarly, the median PLR of patients in the deceased group (268.9 [150-3000]) was significantly higher than that of patients in the survivor group (55.7 [11.8-152.5]). The difference in the PLR between groups was significant (P &lt; .001). Conclusion: Both the NLR and PLR, as well as C-reactive protein, predicted mortality in this critically ill population. The PLR and NLR are easy-to-measure, inexpensive markers. Physicians should be aware of elevations in PLR and NLR in patient care in ICUs.</description><identifier>ISSN: 0885-0666</identifier><identifier>EISSN: 1525-1489</identifier><identifier>DOI: 10.1177/0885066617753389</identifier><identifier>PMID: 29334832</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aged ; Biomarkers - blood ; Blood Cell Count - methods ; Blood Cell Count - statistics &amp; numerical data ; Blood Platelets ; Critical Care Outcomes ; Critical Illness - mortality ; Female ; Hospital Mortality ; Humans ; Intensive Care Units - statistics &amp; numerical data ; Length of Stay - statistics &amp; numerical data ; Lymphocytes ; Male ; Middle Aged ; Neutrophils ; Predictive Value of Tests ; Prognosis ; Retrospective Studies</subject><ispartof>Journal of intensive care medicine, 2020-04, Vol.35 (4), p.383-385</ispartof><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-25f565913fd726f40a3d022b34b7d55cd6c0b2e451e5528831900186de0e1a8b3</citedby><cites>FETCH-LOGICAL-c337t-25f565913fd726f40a3d022b34b7d55cd6c0b2e451e5528831900186de0e1a8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906,79113</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29334832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoldas, Hamit</creatorcontrib><creatorcontrib>Karagoz, Ibrahim</creatorcontrib><creatorcontrib>Ogun, Muhammed Nur</creatorcontrib><creatorcontrib>Velioglu, Yusuf</creatorcontrib><creatorcontrib>Yildiz, Isa</creatorcontrib><creatorcontrib>Bilgi, Murat</creatorcontrib><creatorcontrib>Demirhan, Abdullah</creatorcontrib><title>Novel Mortality Markers for Critically Ill Patients</title><title>Journal of intensive care medicine</title><addtitle>J Intensive Care Med</addtitle><description>Aim: Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess the usefulness of the NLR and PLR as markers of hospital stay and mortality of patients in intensive care units (ICUs). Methods: Patients treated in the ICU of our institution between October 2016 and August 2017 were enrolled in the study. After obtaining approval from the institutional committee, patient data were sourced from the institution’s computerized database and retrospectively analyzed. The patients were assigned to 2 groups according to the outcomes: survivors and deceased. Results: The NLR of survivors and deceased patients was 2.06 (1.18-21.68) and 10.42 (2.85-48.2), respectively. The NLR was significantly elevated in deceased patients as compared with that of survivors (P &lt; .001). Similarly, the median PLR of patients in the deceased group (268.9 [150-3000]) was significantly higher than that of patients in the survivor group (55.7 [11.8-152.5]). The difference in the PLR between groups was significant (P &lt; .001). Conclusion: Both the NLR and PLR, as well as C-reactive protein, predicted mortality in this critically ill population. The PLR and NLR are easy-to-measure, inexpensive markers. Physicians should be aware of elevations in PLR and NLR in patient care in ICUs.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Blood Cell Count - methods</subject><subject>Blood Cell Count - statistics &amp; numerical data</subject><subject>Blood Platelets</subject><subject>Critical Care Outcomes</subject><subject>Critical Illness - mortality</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Intensive Care Units - statistics &amp; numerical data</subject><subject>Length of Stay - statistics &amp; numerical data</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>0885-0666</issn><issn>1525-1489</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kL1PwzAQxS0EoqWwM6GMLAHbFzv2iCo-KrXAALPlJBeU4tbFdpD635OqwIDEdCe933u6e4ScM3rFWFleU6UElVIOuwBQ-oCMmeAiZ4XSh2S8k_OdPiInMS4pZcCBHZMR1wCFAj4m8Og_0WULH5J1XdpmCxveMcSs9SGbhi51tXVum82cy55t6nCd4ik5aq2LePY9J-T17vZl-pDPn-5n05t5XgOUKeeiFVJoBm1TctkW1EJDOa-gqMpGiLqRNa04FoKhEFwpYHq4UMkGKTKrKpiQy33uJviPHmMyqy7W6Jxdo--jYVppoUotiwGle7QOPsaArdmEbmXD1jBqdlWZv1UNlovv9L5aYfNr-OlmAPI9EO0bmqXvw3r49v_ALyxKboE</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Yoldas, Hamit</creator><creator>Karagoz, Ibrahim</creator><creator>Ogun, Muhammed Nur</creator><creator>Velioglu, Yusuf</creator><creator>Yildiz, Isa</creator><creator>Bilgi, Murat</creator><creator>Demirhan, Abdullah</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202004</creationdate><title>Novel Mortality Markers for Critically Ill Patients</title><author>Yoldas, Hamit ; Karagoz, Ibrahim ; Ogun, Muhammed Nur ; Velioglu, Yusuf ; Yildiz, Isa ; Bilgi, Murat ; Demirhan, Abdullah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-25f565913fd726f40a3d022b34b7d55cd6c0b2e451e5528831900186de0e1a8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Blood Cell Count - methods</topic><topic>Blood Cell Count - statistics &amp; numerical data</topic><topic>Blood Platelets</topic><topic>Critical Care Outcomes</topic><topic>Critical Illness - mortality</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Intensive Care Units - statistics &amp; numerical data</topic><topic>Length of Stay - statistics &amp; numerical data</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutrophils</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoldas, Hamit</creatorcontrib><creatorcontrib>Karagoz, Ibrahim</creatorcontrib><creatorcontrib>Ogun, Muhammed Nur</creatorcontrib><creatorcontrib>Velioglu, Yusuf</creatorcontrib><creatorcontrib>Yildiz, Isa</creatorcontrib><creatorcontrib>Bilgi, Murat</creatorcontrib><creatorcontrib>Demirhan, Abdullah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoldas, Hamit</au><au>Karagoz, Ibrahim</au><au>Ogun, Muhammed Nur</au><au>Velioglu, Yusuf</au><au>Yildiz, Isa</au><au>Bilgi, Murat</au><au>Demirhan, Abdullah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel Mortality Markers for Critically Ill Patients</atitle><jtitle>Journal of intensive care medicine</jtitle><addtitle>J Intensive Care Med</addtitle><date>2020-04</date><risdate>2020</risdate><volume>35</volume><issue>4</issue><spage>383</spage><epage>385</epage><pages>383-385</pages><issn>0885-0666</issn><eissn>1525-1489</eissn><abstract>Aim: Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess the usefulness of the NLR and PLR as markers of hospital stay and mortality of patients in intensive care units (ICUs). Methods: Patients treated in the ICU of our institution between October 2016 and August 2017 were enrolled in the study. After obtaining approval from the institutional committee, patient data were sourced from the institution’s computerized database and retrospectively analyzed. The patients were assigned to 2 groups according to the outcomes: survivors and deceased. Results: The NLR of survivors and deceased patients was 2.06 (1.18-21.68) and 10.42 (2.85-48.2), respectively. The NLR was significantly elevated in deceased patients as compared with that of survivors (P &lt; .001). Similarly, the median PLR of patients in the deceased group (268.9 [150-3000]) was significantly higher than that of patients in the survivor group (55.7 [11.8-152.5]). The difference in the PLR between groups was significant (P &lt; .001). Conclusion: Both the NLR and PLR, as well as C-reactive protein, predicted mortality in this critically ill population. The PLR and NLR are easy-to-measure, inexpensive markers. Physicians should be aware of elevations in PLR and NLR in patient care in ICUs.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>29334832</pmid><doi>10.1177/0885066617753389</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0885-0666
ispartof Journal of intensive care medicine, 2020-04, Vol.35 (4), p.383-385
issn 0885-0666
1525-1489
language eng
recordid cdi_proquest_miscellaneous_1989587964
source SAGE
subjects Aged
Biomarkers - blood
Blood Cell Count - methods
Blood Cell Count - statistics & numerical data
Blood Platelets
Critical Care Outcomes
Critical Illness - mortality
Female
Hospital Mortality
Humans
Intensive Care Units - statistics & numerical data
Length of Stay - statistics & numerical data
Lymphocytes
Male
Middle Aged
Neutrophils
Predictive Value of Tests
Prognosis
Retrospective Studies
title Novel Mortality Markers for Critically Ill Patients
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T09%3A25%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Novel%20Mortality%20Markers%20for%20Critically%20Ill%20Patients&rft.jtitle=Journal%20of%20intensive%20care%20medicine&rft.au=Yoldas,%20Hamit&rft.date=2020-04&rft.volume=35&rft.issue=4&rft.spage=383&rft.epage=385&rft.pages=383-385&rft.issn=0885-0666&rft.eissn=1525-1489&rft_id=info:doi/10.1177/0885066617753389&rft_dat=%3Cproquest_cross%3E1989587964%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c337t-25f565913fd726f40a3d022b34b7d55cd6c0b2e451e5528831900186de0e1a8b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1989587964&rft_id=info:pmid/29334832&rft_sage_id=10.1177_0885066617753389&rfr_iscdi=true