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Novel Mortality Markers for Critically Ill Patients
Aim: Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess th...
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Published in: | Journal of intensive care medicine 2020-04, Vol.35 (4), p.383-385 |
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container_end_page | 385 |
container_issue | 4 |
container_start_page | 383 |
container_title | Journal of intensive care medicine |
container_volume | 35 |
creator | Yoldas, Hamit Karagoz, Ibrahim Ogun, Muhammed Nur Velioglu, Yusuf Yildiz, Isa Bilgi, Murat Demirhan, Abdullah |
description | Aim:
Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess the usefulness of the NLR and PLR as markers of hospital stay and mortality of patients in intensive care units (ICUs).
Methods:
Patients treated in the ICU of our institution between October 2016 and August 2017 were enrolled in the study. After obtaining approval from the institutional committee, patient data were sourced from the institution’s computerized database and retrospectively analyzed. The patients were assigned to 2 groups according to the outcomes: survivors and deceased.
Results:
The NLR of survivors and deceased patients was 2.06 (1.18-21.68) and 10.42 (2.85-48.2), respectively. The NLR was significantly elevated in deceased patients as compared with that of survivors (P < .001). Similarly, the median PLR of patients in the deceased group (268.9 [150-3000]) was significantly higher than that of patients in the survivor group (55.7 [11.8-152.5]). The difference in the PLR between groups was significant (P < .001).
Conclusion:
Both the NLR and PLR, as well as C-reactive protein, predicted mortality in this critically ill population. The PLR and NLR are easy-to-measure, inexpensive markers. Physicians should be aware of elevations in PLR and NLR in patient care in ICUs. |
doi_str_mv | 10.1177/0885066617753389 |
format | article |
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Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess the usefulness of the NLR and PLR as markers of hospital stay and mortality of patients in intensive care units (ICUs).
Methods:
Patients treated in the ICU of our institution between October 2016 and August 2017 were enrolled in the study. After obtaining approval from the institutional committee, patient data were sourced from the institution’s computerized database and retrospectively analyzed. The patients were assigned to 2 groups according to the outcomes: survivors and deceased.
Results:
The NLR of survivors and deceased patients was 2.06 (1.18-21.68) and 10.42 (2.85-48.2), respectively. The NLR was significantly elevated in deceased patients as compared with that of survivors (P < .001). Similarly, the median PLR of patients in the deceased group (268.9 [150-3000]) was significantly higher than that of patients in the survivor group (55.7 [11.8-152.5]). The difference in the PLR between groups was significant (P < .001).
Conclusion:
Both the NLR and PLR, as well as C-reactive protein, predicted mortality in this critically ill population. The PLR and NLR are easy-to-measure, inexpensive markers. Physicians should be aware of elevations in PLR and NLR in patient care in ICUs.</description><identifier>ISSN: 0885-0666</identifier><identifier>EISSN: 1525-1489</identifier><identifier>DOI: 10.1177/0885066617753389</identifier><identifier>PMID: 29334832</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aged ; Biomarkers - blood ; Blood Cell Count - methods ; Blood Cell Count - statistics & numerical data ; Blood Platelets ; Critical Care Outcomes ; Critical Illness - mortality ; Female ; Hospital Mortality ; Humans ; Intensive Care Units - statistics & numerical data ; Length of Stay - statistics & numerical data ; Lymphocytes ; Male ; Middle Aged ; Neutrophils ; Predictive Value of Tests ; Prognosis ; Retrospective Studies</subject><ispartof>Journal of intensive care medicine, 2020-04, Vol.35 (4), p.383-385</ispartof><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-25f565913fd726f40a3d022b34b7d55cd6c0b2e451e5528831900186de0e1a8b3</citedby><cites>FETCH-LOGICAL-c337t-25f565913fd726f40a3d022b34b7d55cd6c0b2e451e5528831900186de0e1a8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906,79113</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29334832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoldas, Hamit</creatorcontrib><creatorcontrib>Karagoz, Ibrahim</creatorcontrib><creatorcontrib>Ogun, Muhammed Nur</creatorcontrib><creatorcontrib>Velioglu, Yusuf</creatorcontrib><creatorcontrib>Yildiz, Isa</creatorcontrib><creatorcontrib>Bilgi, Murat</creatorcontrib><creatorcontrib>Demirhan, Abdullah</creatorcontrib><title>Novel Mortality Markers for Critically Ill Patients</title><title>Journal of intensive care medicine</title><addtitle>J Intensive Care Med</addtitle><description>Aim:
Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess the usefulness of the NLR and PLR as markers of hospital stay and mortality of patients in intensive care units (ICUs).
Methods:
Patients treated in the ICU of our institution between October 2016 and August 2017 were enrolled in the study. After obtaining approval from the institutional committee, patient data were sourced from the institution’s computerized database and retrospectively analyzed. The patients were assigned to 2 groups according to the outcomes: survivors and deceased.
Results:
The NLR of survivors and deceased patients was 2.06 (1.18-21.68) and 10.42 (2.85-48.2), respectively. The NLR was significantly elevated in deceased patients as compared with that of survivors (P < .001). Similarly, the median PLR of patients in the deceased group (268.9 [150-3000]) was significantly higher than that of patients in the survivor group (55.7 [11.8-152.5]). The difference in the PLR between groups was significant (P < .001).
Conclusion:
Both the NLR and PLR, as well as C-reactive protein, predicted mortality in this critically ill population. The PLR and NLR are easy-to-measure, inexpensive markers. Physicians should be aware of elevations in PLR and NLR in patient care in ICUs.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Blood Cell Count - methods</subject><subject>Blood Cell Count - statistics & numerical data</subject><subject>Blood Platelets</subject><subject>Critical Care Outcomes</subject><subject>Critical Illness - mortality</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Intensive Care Units - statistics & numerical data</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>0885-0666</issn><issn>1525-1489</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kL1PwzAQxS0EoqWwM6GMLAHbFzv2iCo-KrXAALPlJBeU4tbFdpD635OqwIDEdCe933u6e4ScM3rFWFleU6UElVIOuwBQ-oCMmeAiZ4XSh2S8k_OdPiInMS4pZcCBHZMR1wCFAj4m8Og_0WULH5J1XdpmCxveMcSs9SGbhi51tXVum82cy55t6nCd4ik5aq2LePY9J-T17vZl-pDPn-5n05t5XgOUKeeiFVJoBm1TctkW1EJDOa-gqMpGiLqRNa04FoKhEFwpYHq4UMkGKTKrKpiQy33uJviPHmMyqy7W6Jxdo--jYVppoUotiwGle7QOPsaArdmEbmXD1jBqdlWZv1UNlovv9L5aYfNr-OlmAPI9EO0bmqXvw3r49v_ALyxKboE</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Yoldas, Hamit</creator><creator>Karagoz, Ibrahim</creator><creator>Ogun, Muhammed Nur</creator><creator>Velioglu, Yusuf</creator><creator>Yildiz, Isa</creator><creator>Bilgi, Murat</creator><creator>Demirhan, Abdullah</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202004</creationdate><title>Novel Mortality Markers for Critically Ill Patients</title><author>Yoldas, Hamit ; Karagoz, Ibrahim ; Ogun, Muhammed Nur ; Velioglu, Yusuf ; Yildiz, Isa ; Bilgi, Murat ; Demirhan, Abdullah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-25f565913fd726f40a3d022b34b7d55cd6c0b2e451e5528831900186de0e1a8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Blood Cell Count - methods</topic><topic>Blood Cell Count - statistics & numerical data</topic><topic>Blood Platelets</topic><topic>Critical Care Outcomes</topic><topic>Critical Illness - mortality</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Intensive Care Units - statistics & numerical data</topic><topic>Length of Stay - statistics & numerical data</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutrophils</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoldas, Hamit</creatorcontrib><creatorcontrib>Karagoz, Ibrahim</creatorcontrib><creatorcontrib>Ogun, Muhammed Nur</creatorcontrib><creatorcontrib>Velioglu, Yusuf</creatorcontrib><creatorcontrib>Yildiz, Isa</creatorcontrib><creatorcontrib>Bilgi, Murat</creatorcontrib><creatorcontrib>Demirhan, Abdullah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoldas, Hamit</au><au>Karagoz, Ibrahim</au><au>Ogun, Muhammed Nur</au><au>Velioglu, Yusuf</au><au>Yildiz, Isa</au><au>Bilgi, Murat</au><au>Demirhan, Abdullah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel Mortality Markers for Critically Ill Patients</atitle><jtitle>Journal of intensive care medicine</jtitle><addtitle>J Intensive Care Med</addtitle><date>2020-04</date><risdate>2020</risdate><volume>35</volume><issue>4</issue><spage>383</spage><epage>385</epage><pages>383-385</pages><issn>0885-0666</issn><eissn>1525-1489</eissn><abstract>Aim:
Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess the usefulness of the NLR and PLR as markers of hospital stay and mortality of patients in intensive care units (ICUs).
Methods:
Patients treated in the ICU of our institution between October 2016 and August 2017 were enrolled in the study. After obtaining approval from the institutional committee, patient data were sourced from the institution’s computerized database and retrospectively analyzed. The patients were assigned to 2 groups according to the outcomes: survivors and deceased.
Results:
The NLR of survivors and deceased patients was 2.06 (1.18-21.68) and 10.42 (2.85-48.2), respectively. The NLR was significantly elevated in deceased patients as compared with that of survivors (P < .001). Similarly, the median PLR of patients in the deceased group (268.9 [150-3000]) was significantly higher than that of patients in the survivor group (55.7 [11.8-152.5]). The difference in the PLR between groups was significant (P < .001).
Conclusion:
Both the NLR and PLR, as well as C-reactive protein, predicted mortality in this critically ill population. The PLR and NLR are easy-to-measure, inexpensive markers. Physicians should be aware of elevations in PLR and NLR in patient care in ICUs.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>29334832</pmid><doi>10.1177/0885066617753389</doi><tpages>3</tpages></addata></record> |
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subjects | Aged Biomarkers - blood Blood Cell Count - methods Blood Cell Count - statistics & numerical data Blood Platelets Critical Care Outcomes Critical Illness - mortality Female Hospital Mortality Humans Intensive Care Units - statistics & numerical data Length of Stay - statistics & numerical data Lymphocytes Male Middle Aged Neutrophils Predictive Value of Tests Prognosis Retrospective Studies |
title | Novel Mortality Markers for Critically Ill Patients |
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