The CRISPR-Cas system in Enterobacteriaceae

Abstract In nature, microorganisms are constantly exposed to multiple viral infections and thus have developed many strategies to survive phage attack and invasion by foreign DNA. One of such strategies is the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated prote...

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Bibliographic Details
Published in:Pathogens and disease 2018-02, Vol.76 (1)
Main Authors: Medina-Aparicio, Liliana, Dávila, Sonia, Rebollar-Flores, Javier E, Calva, Edmundo, Hernández-Lucas, Ismael
Format: Article
Language:English
Subjects:
CRISPR
Deoxyribonucleic acid
DNA
Editing
Enterobacteriaceae
Gene regulation
Genome editing
Genomes
Immunology
Microorganisms
Phages
Prokaryotes
Proteins
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Summary:Abstract In nature, microorganisms are constantly exposed to multiple viral infections and thus have developed many strategies to survive phage attack and invasion by foreign DNA. One of such strategies is the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) bacterial immunological system. This defense mechanism is widespread in prokaryotes including several families such as Enterobacteriaceae. Much knowledge about the CRISPR-Cas system has been generated, including its biological functions, transcriptional regulation, distribution, utility as a molecular marker and as a tool for specific genome editing. This review focuses on these aspects and describes the state of the art of the CRISPR-Cas system in the Enterobacteriaceae bacterial family. The CRISPR-Cas system in Enterobacteriaceae: biological functions, transcriptional regulation, distribution, utility as a molecular marker and as a tool for specific genome editing.
ISSN:2049-632X
2049-632X
DOI:10.1093/femspd/fty002