Does oxidative stress contribute to adverse outcomes in HIV-associated TB?

In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2018-05, Vol.73 (5), p.1117-1120
Main Authors: Yew, Wing-Wai, Chan, Denise P, Singhal, Amit, Zhang, Ying, Lee, Shui-Shan
Format: Article
Language:English
Subjects:
HIV Infections - complications
Humans
Mycobacterium Infections - pathology
Oxidative Stress
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes of TB, probably through increased propensity for generation of metabolically dormant mycobacterial persisters, alongside other mechanisms. This hypothesis might help in guiding the exploration of relevant research directions to improve the care of patients.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkx509