MicroRNA-30c as a novel diagnostic biomarker for primary and secondary B-cell lymphoma of the CNS

Primary lymphomas of the central nervous system (PCNSL) are highly aggressive tumors affecting exclusively the CNS, meninges, and eyes. PCNSL must be separated from secondary spread of systemic lymphoma to the CNS (SCNSL), which may occur at diagnosis or relapse of systemic lymphomas. At present, th...

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Bibliographic Details
Published in:Journal of neuro-oncology 2018-05, Vol.137 (3), p.463-468
Main Authors: Baraniskin, Alexander, Chomiak, Monika, Ahle, Guido, Gress, Thomas, Buchholz, Malte, Turewicz, Michael, Eisenacher, Martin, Margold, Michelle, Schlegel, Uwe, Schmiegel, Wolff, Hahn, Stephan, Schroers, Roland
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
B-cell lymphoma
Biomarkers, Tumor - blood
Biomarkers, Tumor - cerebrospinal fluid
Biopsy
Celsr3 protein
Central nervous system
Central Nervous System Neoplasms - blood
Central Nervous System Neoplasms - cerebrospinal fluid
Central Nervous System Neoplasms - secondary
Cilia
Computer Simulation
Diagnosis, Differential
Female
Humans
Laboratory Investigation
Lymphocytes B
Lymphoma
Lymphoma, Large B-Cell, Diffuse - blood
Lymphoma, Large B-Cell, Diffuse - cerebrospinal fluid
Lymphoma, Large B-Cell, Diffuse - pathology
Male
Medicine
Medicine & Public Health
Meninges
MicroRNAs
MicroRNAs - blood
MicroRNAs - cerebrospinal fluid
Middle Aged
miRNA
Neurology
Oncology
Polymerase chain reaction
Sensitivity and Specificity
Tumors
Young Adult
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Description
Summary:Primary lymphomas of the central nervous system (PCNSL) are highly aggressive tumors affecting exclusively the CNS, meninges, and eyes. PCNSL must be separated from secondary spread of systemic lymphoma to the CNS (SCNSL), which may occur at diagnosis or relapse of systemic lymphomas. At present, there are no valid methods to distinguish PCNSL from SCNSL based on tumor biopsy because of similar histological presentation. However, SCNSL and PCNSL are different in terms of prognosis and adequate therapy protocols. MicroRNA expression profiles of CSF samples collected from SCNSL and PCNSL patients were compared using microRNA arrays. MiR-30c revealed the largest differential expression and was selected for validation by RT-PCR on 61 CSF samples from patients with PCNSL and 14 samples from SCNSL. MiR-30c was significantly increased in patients with SCNSL compared to PCNSL ( p  
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-018-2749-0