Population-based serum omentin-1 levels: paradoxical association with cardiometabolic disorders primarily in men

• Published in: Biomarkers in medicine 2018-02, Vol.12 (2), p.141-149
• Main Authors: Onat, Altan, Ademoglu, Evin, Karadeniz, Yusuf, Can, Gunay, Uzun, Ahmet Okan, Simsek, Bar s, Kaya, Aysem
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anti-inflammatory agents; autoimmunity; Biomarkers - blood; Blood Glucose - analysis; Blood Pressure; cardiometabolic risk; Cardiovascular disease; Cytokines - blood; Diabetes mellitus; Female; gender difference; Glycated Hemoglobin A - analysis; GPI-Linked Proteins - blood; Health risk assessment; Humans; Inflammation; Insulin resistance; Lectins - blood; Likelihood Functions; lipoprotein(a); Lipoprotein(a) - blood; Logistic Models; Male; Metabolic syndrome; Metabolic Syndrome - diagnosis; Middle Aged; Odds Ratio; omentin-1; Oxidative stress; Risk Factors; Womens health
• ISSN: 1752-0363; 1752-0371
• DOI: 10.2217/bmm-2017-0197

The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic blood pressure, HbA1c and glucose values and tended in T3 to higher lipoprotein(a) levels. Logistic regression analysis, adjusted for four covariates, revealed significant independent associations with the presence of hypertension and diabetes only in men. Sex- and age-adjusted odds ratio in gender combined for T2 & T3 versus T1 was 1.34 (95% CI: 1.00-1.79) for metabolic syndrome. The elicited adverse relationships of omentin-1 support the notion of oxidative stress-induced proinflammatory conversion of omentin, rendering loss of anti-inflammatory properties.