Quantification of osteoblastic activity in epiphyseal growth plates by quantitative bone SPECT/CT

Objective Quantifying the function of the epiphyseal plate is worthwhile for the management of children with growth disorders. The aim of this retrospective study was to quantify the osteoblastic activity at the epiphyseal plate using the quantitative bone SPECT/CT. Materials and methods We enrolled...

Full description

Saved in:
Bibliographic Details
Published in:Skeletal radiology 2018-06, Vol.47 (6), p.805-810
Main Authors: Yamane, Tomohiko, Kuji, Ichiei, Seto, Akira, Matsunari, Ichiro
Format: Article
Language:English
Subjects:
Adolescent
Age
Aging
Biocompatibility
Body height
Bone growth
Child
Children
Computed tomography
Correlation analysis
Female
Femur
Growth Plate - diagnostic imaging
Humans
Image acquisition
Image reconstruction
Imaging
Legs
Lower Extremity - diagnostic imaging
Lower Extremity - growth & development
Male
Medicine
Medicine & Public Health
Multimodal Imaging
Nuclear Medicine
Orthopedics
Osteoblasts
Osteoblasts - physiology
Pathology
Patients
Radiology
Radiopharmaceuticals
Retrospective Studies
Scientific Article
Scintigraphy
Single photon emission computed tomography
Technetium Tc 99m Medronate - analogs & derivatives
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Velocity
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective Quantifying the function of the epiphyseal plate is worthwhile for the management of children with growth disorders. The aim of this retrospective study was to quantify the osteoblastic activity at the epiphyseal plate using the quantitative bone SPECT/CT. Materials and methods We enrolled patients under the age of 20 years who received Tc-99m hydroxymethylene diphosphonate bone scintigraphy acquired by a quantitative SPECT/CT scanner. The images were reconstructed by ordered subset conjugate-gradient minimizer, and the uptake on the distal margin of the femur was quantified by peak standardized uptake value (SUVpeak). A public database of standard body height was used to calculate growth velocities (cm/year). Results Fifteen patients (6.9–19.7 years, 9 female, 6 male) were enrolled and a total of 25 legs were analyzed. SUVpeak in the epiphyseal plate was 18.9 ± 2.4 (average ± standard deviation) in the subjects under 15 years and decreased gradually by aging. The SUVpeak correlated significantly with the age- and sex-matched growth velocity obtained from the database ( R 2  = 0.83, p  
ISSN:0364-2348
1432-2161
DOI:10.1007/s00256-017-2861-9