Evolutionary and genetic features of drug targets

In the modern drug discovery pipeline, identification of novel drug targets is a critical step. Despite rapid progress in developing biomedical techniques, it is still a great challenge to find promising new targets from the ample space of human genes. This fact is partially responsible for the situ...

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Bibliographic Details
Published in:Medicinal research reviews 2018-09, Vol.38 (5), p.1536-1549
Main Authors: Quan, Yuan, Wang, Zhong‐Yi, Chu, Xin‐Yi, Zhang, Hong‐Yu
Format: Article
Language:English
Subjects:
Drug Delivery Systems
Drug Discovery
drug target
Evolution, Molecular
evolutionary biology
Genes
genetics
Humans
Molecular Targeted Therapy
Pharmaceutical industry
Pharmaceutical Preparations
Pharmacology
R&D
Research & development
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Summary:In the modern drug discovery pipeline, identification of novel drug targets is a critical step. Despite rapid progress in developing biomedical techniques, it is still a great challenge to find promising new targets from the ample space of human genes. This fact is partially responsible for the situation of “more investments, fewer drugs” in the pharmaceutical industry. A series of recent researches revealed that successfully targeted genes share some common evolutionary and genetic features, which means that the knowledge accumulated in modern evolutionary biology and genetics is very helpful to identify potential drug targets and to find new drugs as well. In this article, we comprehensively summarize the links between human drug targets and genetic diseases and their evolutionary origins, with an attempt to introduce these novel concepts and their medical implications to the biomedical community.
ISSN:0198-6325
1098-1128
DOI:10.1002/med.21487