Coagulase-negative staphylococci are associated to the mild inflammatory pattern of healthcare-associated meningitis: a retrospective study

The epidemiology of healthcare-associated meningitis (HAM) is dominated by commensal bacteria from the skin, as coagulase-negative staphylococci (CoNS). We hypothesized that the pauci-symptomatic and mild inflammatory patterns of HAM are related to the low pathogenic state of CoNS. Our aim was to de...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2018-04, Vol.37 (4), p.755-763
Main Authors: Couffin, S., Lobo, D., Cook, F., Jost, P. H., Bitot, V., Birnbaum, R., Nebbad, B., Aït-Mamar, B., Lahiani, W., Martin, M., Dhonneur, G., Mounier, R.
Format: Article
Language:English
Subjects:
Bacteria
Biomedical and Life Sciences
Biomedicine
Cerebrospinal fluid
Coagulase
Coma
Epidemiology
Health care
Inflammation
Internal Medicine
Medical Microbiology
Meningitis
Original Article
Patients
Pleocytosis
Skin
Surgery
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Summary:The epidemiology of healthcare-associated meningitis (HAM) is dominated by commensal bacteria from the skin, as coagulase-negative staphylococci (CoNS). We hypothesized that the pauci-symptomatic and mild inflammatory patterns of HAM are related to the low pathogenic state of CoNS. Our aim was to describe clinical and biological features of CoNS HAM, compared to other HAM. All consecutive patients with HAM admitted in our hospital were retrospectively included from 2007 to 2014. HAM due to CoNS were compared to HAM caused by other bacteria (controls) for clinical and laboratory patterns. Seventy-one cases of HAM were included, comprising 18 CoNS and 53 controls. Patients were not different in terms of baseline characteristics. CoNS HAM occurred later after the last surgery than controls (17 vs. 12 days, p  = 0.029) and had higher Glasgow Coma Scale (GCS) score (14 vs. 13, p  = 0.038). Cerebrospinal fluid (CSF) analysis revealed a lower pleocytosis (25 vs. 1340/mm 3 , p  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-017-3171-9