Brain oxygenation with a non‐vasoactive perfluorocarbon emulsion in a rat model of traumatic brain injury

Objective The aim of this study was to assess, in two experiments, the safety and efficacy of the PFC emulsion Oxycyte as an oxygen therapeutic for TBI to test the hypothesis that early administration of this oxygen‐carrying fluid post‐TBI would improve brain tissue oxygenation (PbtO2). Methods The...

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Bibliographic Details
Published in:Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2018-04, Vol.25 (3), p.e12441-n/a
Main Authors: Abutarboush, Rania, Mullah, Saad H., Saha, Biswajit K., Haque, Ashraful, Walker, Peter B., Aligbe, Chioma, Pappas, Georgina, Tran Ho, Lam Thuy Vi, Arnaud, Francoise G., Auker, Charles R., McCarron, Richard M., Scultetus, Anke H., Moon‐Massat, Paula
Format: Article
Language:English
Subjects:
Animals
Arterioles - physiology
Brain - metabolism
Brain Injuries, Traumatic - therapy
Cerebrovascular Circulation
controlled cortical impact
Fluorocarbons - therapeutic use
Intravital Microscopy
Oxygen - administration & dosage
Oxygen - blood
oxygen therapeutic
phosphorescence quenching method
pial microcirculation
Rats
Rodents
Traumatic brain injury
Vasoconstriction - drug effects
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Summary:Objective The aim of this study was to assess, in two experiments, the safety and efficacy of the PFC emulsion Oxycyte as an oxygen therapeutic for TBI to test the hypothesis that early administration of this oxygen‐carrying fluid post‐TBI would improve brain tissue oxygenation (PbtO2). Methods The first experiment assessed the effects of Oxycyte on cerebral vasoactivity in healthy, uninjured rats using intravital microscopy. The second experiment investigated the effect of Oxycyte on cerebral PbtO2 using the PQM in TBI model. Animals in the Oxycyte group received a single injection of Oxycyte (6 mL/kg) shortly after TBI, while NON animals received no treatment. Results Oxycyte did not cause vasoconstriction in small‐ (
ISSN:1073-9688
1549-8719
DOI:10.1111/micc.12441