Sustainable Radical Cascades to Synthesize Difluoroalkylated Pyrrolo[1,2‑a]indoles

We disclose herein a photocatalytic difluoroalkylation and cyclization cascade reaction of N-(but-2-enoyl)­indoles with broad substrate scopes in up to 90% isolated yield. This method provides sustainable and efficient access to synthesize difluoroalkylated pyrrolo­[1,2-a]­indoles with a quaternary...

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Bibliographic Details
Published in:Journal of organic chemistry 2018-02, Vol.83 (4), p.2425-2437
Main Authors: Huang, Honggui, Yu, Menglin, Su, Xiaolong, Guo, Peng, Zhao, Jia, Zhou, Jiabing, Li, Yi
Format: Article
Language:English
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Summary:We disclose herein a photocatalytic difluoroalkylation and cyclization cascade reaction of N-(but-2-enoyl)­indoles with broad substrate scopes in up to 90% isolated yield. This method provides sustainable and efficient access to synthesize difluoroalkylated pyrrolo­[1,2-a]­indoles with a quaternary carbon center under mild conditions.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b03017