Sustainable Radical Cascades to Synthesize Difluoroalkylated Pyrrolo[1,2‑a]indoles

We disclose herein a photocatalytic difluoroalkylation and cyclization cascade reaction of N-(but-2-enoyl)­indoles with broad substrate scopes in up to 90% isolated yield. This method provides sustainable and efficient access to synthesize difluoroalkylated pyrrolo­[1,2-a]­indoles with a quaternary...

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Published in:Journal of organic chemistry 2018-02, Vol.83 (4), p.2425-2437
Main Authors: Huang, Honggui, Yu, Menglin, Su, Xiaolong, Guo, Peng, Zhao, Jia, Zhou, Jiabing, Li, Yi
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Language:English
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cited_by cdi_FETCH-LOGICAL-a333t-5092b9a214149d4d09d29e10f51462dd23f7db6755c1a5dca973346d537659743
cites cdi_FETCH-LOGICAL-a333t-5092b9a214149d4d09d29e10f51462dd23f7db6755c1a5dca973346d537659743
container_end_page 2437
container_issue 4
container_start_page 2425
container_title Journal of organic chemistry
container_volume 83
creator Huang, Honggui
Yu, Menglin
Su, Xiaolong
Guo, Peng
Zhao, Jia
Zhou, Jiabing
Li, Yi
description We disclose herein a photocatalytic difluoroalkylation and cyclization cascade reaction of N-(but-2-enoyl)­indoles with broad substrate scopes in up to 90% isolated yield. This method provides sustainable and efficient access to synthesize difluoroalkylated pyrrolo­[1,2-a]­indoles with a quaternary carbon center under mild conditions.
doi_str_mv 10.1021/acs.joc.7b03017
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title Sustainable Radical Cascades to Synthesize Difluoroalkylated Pyrrolo[1,2‑a]indoles
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