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Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats
Feline lymphomas are associated with the transduction and activation of cellular proto-oncogenes, such as c- myc , by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of myc transduction usable in clinical diagnosis. The assay targets c- myc exons 2 and 3, wh...
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| Published in: | Archives of virology 2018-04, Vol.163 (4), p.1073-1077 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c438t-30823e0370cfad45ca05e8c17e42991b295357d12e5e9b5dc4ade604200302803 |
| container_end_page | 1077 |
| container_issue | 4 |
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| container_title | Archives of virology |
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| creator | Sumi, Ryosuke Miyake, Ariko Endo, Taiji Ohsato, Yoshiharu Ngo, Minh Ha Nishigaki, Kazuo |
| description | Feline lymphomas are associated with the transduction and activation of cellular proto-oncogenes, such as c-
myc
, by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of
myc
transduction usable in clinical diagnosis. The assay targets c-
myc
exons 2 and 3, which together result in a FeLV-specific fusion gene following c-
myc
transduction. When this assay was conducted on FeLV-infected feline tissues submitted for clinical diagnosis of tumors,
myc
transduction was detected in 14% of T-cell lymphoma/leukemias. This newly established system could become a useful diagnostic tool in veterinary medicine. |
| doi_str_mv | 10.1007/s00705-018-3721-1 |
| format | article |
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myc
, by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of
myc
transduction usable in clinical diagnosis. The assay targets c-
myc
exons 2 and 3, which together result in a FeLV-specific fusion gene following c-
myc
transduction. When this assay was conducted on FeLV-infected feline tissues submitted for clinical diagnosis of tumors,
myc
transduction was detected in 14% of T-cell lymphoma/leukemias. This newly established system could become a useful diagnostic tool in veterinary medicine.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-018-3721-1</identifier><identifier>PMID: 29353423</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Animals ; B-Lymphocytes - metabolism ; B-Lymphocytes - pathology ; Biomedical and Life Sciences ; Biomedicine ; Brief Report ; c-Myc protein ; Cats ; Diagnosis ; DNA, Viral - genetics ; Exons ; Feline leukemia ; Female ; Fusion protein ; Gene Expression ; Infectious Diseases ; Leukemia ; Leukemia Virus, Feline - genetics ; Leukemia Virus, Feline - isolation & purification ; Leukemia, Feline - diagnosis ; Leukemia, Feline - genetics ; Leukemia, Feline - metabolism ; Leukemia, Feline - pathology ; Lymphocytes T ; Lymphoma, T-Cell - diagnosis ; Lymphoma, T-Cell - genetics ; Lymphoma, T-Cell - metabolism ; Lymphoma, T-Cell - pathology ; Male ; Medical Microbiology ; Myc protein ; Oncogene Proteins, Fusion - genetics ; Oncogene Proteins, Fusion - metabolism ; Polymerase chain reaction ; Polymerase Chain Reaction - methods ; Proto-Oncogene Proteins c-myc - genetics ; Proto-Oncogene Proteins c-myc - metabolism ; Proto-oncogenes ; T-cell lymphoma ; T-Lymphocytes - metabolism ; T-Lymphocytes - pathology ; Transduction, Genetic ; Tumors ; Veterinary medicine ; Virology</subject><ispartof>Archives of virology, 2018-04, Vol.163 (4), p.1073-1077</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2018</rights><rights>Archives of Virology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-30823e0370cfad45ca05e8c17e42991b295357d12e5e9b5dc4ade604200302803</citedby><cites>FETCH-LOGICAL-c438t-30823e0370cfad45ca05e8c17e42991b295357d12e5e9b5dc4ade604200302803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29353423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sumi, Ryosuke</creatorcontrib><creatorcontrib>Miyake, Ariko</creatorcontrib><creatorcontrib>Endo, Taiji</creatorcontrib><creatorcontrib>Ohsato, Yoshiharu</creatorcontrib><creatorcontrib>Ngo, Minh Ha</creatorcontrib><creatorcontrib>Nishigaki, Kazuo</creatorcontrib><title>Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>Feline lymphomas are associated with the transduction and activation of cellular proto-oncogenes, such as c-
myc
, by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of
myc
transduction usable in clinical diagnosis. The assay targets c-
myc
exons 2 and 3, which together result in a FeLV-specific fusion gene following c-
myc
transduction. When this assay was conducted on FeLV-infected feline tissues submitted for clinical diagnosis of tumors,
myc
transduction was detected in 14% of T-cell lymphoma/leukemias. This newly established system could become a useful diagnostic tool in veterinary medicine.</description><subject>Animals</subject><subject>B-Lymphocytes - metabolism</subject><subject>B-Lymphocytes - pathology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brief Report</subject><subject>c-Myc protein</subject><subject>Cats</subject><subject>Diagnosis</subject><subject>DNA, Viral - genetics</subject><subject>Exons</subject><subject>Feline leukemia</subject><subject>Female</subject><subject>Fusion protein</subject><subject>Gene Expression</subject><subject>Infectious Diseases</subject><subject>Leukemia</subject><subject>Leukemia Virus, Feline - genetics</subject><subject>Leukemia Virus, Feline - isolation & purification</subject><subject>Leukemia, Feline - diagnosis</subject><subject>Leukemia, Feline - genetics</subject><subject>Leukemia, Feline - metabolism</subject><subject>Leukemia, Feline - pathology</subject><subject>Lymphocytes T</subject><subject>Lymphoma, T-Cell - diagnosis</subject><subject>Lymphoma, T-Cell - genetics</subject><subject>Lymphoma, T-Cell - metabolism</subject><subject>Lymphoma, T-Cell - pathology</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Myc protein</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>Oncogene Proteins, Fusion - metabolism</subject><subject>Polymerase chain reaction</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Proto-Oncogene Proteins c-myc - genetics</subject><subject>Proto-Oncogene Proteins c-myc - metabolism</subject><subject>Proto-oncogenes</subject><subject>T-cell lymphoma</subject><subject>T-Lymphocytes - metabolism</subject><subject>T-Lymphocytes - pathology</subject><subject>Transduction, Genetic</subject><subject>Tumors</subject><subject>Veterinary medicine</subject><subject>Virology</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kUlLBDEUhIMoOi4_wIs0ePESfdmmk6OIGwh60HPIJK-1tRdNuoX592ZsFRG8JKTyVWUpQvYZHDOA8iTlARQFpqkoOaNsjcyYFJzq0uh1MgMBkuo56C2yndIzQBaE2iRb3AglJBczEu76ZtlidAkL_-Tqrojo_FD3HV1kLRQBB_xcF31VtEtfDNF1KYyTlvkKm7rDosHxBdvaFe91HBOtuyrbst-7Ie2Sjco1Cfe-5h3ycHF-f3ZFb24vr89Ob6iXQg9UgOYCQZTgKxek8g4Uas9KlNwYtuBGCVUGxlGhWajgpQs4B8lX7-IaxA45mnJfY_82YhpsWyePTeM67MdkmdE5Zw5zk9HDP-hzP8Yu3y5TRnBhQJaZYhPlY59SxMq-xrp1cWkZ2FUFdqrA5grsqgLLsufgK3lctBh-HN9_ngE-ASlvdY8Yfx39b-oHs7iQsw</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Sumi, Ryosuke</creator><creator>Miyake, Ariko</creator><creator>Endo, Taiji</creator><creator>Ohsato, Yoshiharu</creator><creator>Ngo, Minh Ha</creator><creator>Nishigaki, Kazuo</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats</title><author>Sumi, Ryosuke ; Miyake, Ariko ; Endo, Taiji ; Ohsato, Yoshiharu ; Ngo, Minh Ha ; Nishigaki, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-30823e0370cfad45ca05e8c17e42991b295357d12e5e9b5dc4ade604200302803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>B-Lymphocytes - metabolism</topic><topic>B-Lymphocytes - pathology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brief Report</topic><topic>c-Myc protein</topic><topic>Cats</topic><topic>Diagnosis</topic><topic>DNA, Viral - genetics</topic><topic>Exons</topic><topic>Feline leukemia</topic><topic>Female</topic><topic>Fusion protein</topic><topic>Gene Expression</topic><topic>Infectious Diseases</topic><topic>Leukemia</topic><topic>Leukemia Virus, Feline - genetics</topic><topic>Leukemia Virus, Feline - isolation & purification</topic><topic>Leukemia, Feline - diagnosis</topic><topic>Leukemia, Feline - genetics</topic><topic>Leukemia, Feline - metabolism</topic><topic>Leukemia, Feline - pathology</topic><topic>Lymphocytes T</topic><topic>Lymphoma, T-Cell - diagnosis</topic><topic>Lymphoma, T-Cell - genetics</topic><topic>Lymphoma, T-Cell - metabolism</topic><topic>Lymphoma, T-Cell - pathology</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Myc protein</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>Oncogene Proteins, Fusion - metabolism</topic><topic>Polymerase chain reaction</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Proto-Oncogene Proteins c-myc - genetics</topic><topic>Proto-Oncogene Proteins c-myc - metabolism</topic><topic>Proto-oncogenes</topic><topic>T-cell lymphoma</topic><topic>T-Lymphocytes - metabolism</topic><topic>T-Lymphocytes - pathology</topic><topic>Transduction, Genetic</topic><topic>Tumors</topic><topic>Veterinary medicine</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sumi, Ryosuke</creatorcontrib><creatorcontrib>Miyake, Ariko</creatorcontrib><creatorcontrib>Endo, Taiji</creatorcontrib><creatorcontrib>Ohsato, Yoshiharu</creatorcontrib><creatorcontrib>Ngo, Minh Ha</creatorcontrib><creatorcontrib>Nishigaki, Kazuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sumi, Ryosuke</au><au>Miyake, Ariko</au><au>Endo, Taiji</au><au>Ohsato, Yoshiharu</au><au>Ngo, Minh Ha</au><au>Nishigaki, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats</atitle><jtitle>Archives of virology</jtitle><stitle>Arch Virol</stitle><addtitle>Arch Virol</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>163</volume><issue>4</issue><spage>1073</spage><epage>1077</epage><pages>1073-1077</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>Feline lymphomas are associated with the transduction and activation of cellular proto-oncogenes, such as c-
myc
, by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of
myc
transduction usable in clinical diagnosis. The assay targets c-
myc
exons 2 and 3, which together result in a FeLV-specific fusion gene following c-
myc
transduction. When this assay was conducted on FeLV-infected feline tissues submitted for clinical diagnosis of tumors,
myc
transduction was detected in 14% of T-cell lymphoma/leukemias. This newly established system could become a useful diagnostic tool in veterinary medicine.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>29353423</pmid><doi>10.1007/s00705-018-3721-1</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals B-Lymphocytes - metabolism B-Lymphocytes - pathology Biomedical and Life Sciences Biomedicine Brief Report c-Myc protein Cats Diagnosis DNA, Viral - genetics Exons Feline leukemia Female Fusion protein Gene Expression Infectious Diseases Leukemia Leukemia Virus, Feline - genetics Leukemia Virus, Feline - isolation & purification Leukemia, Feline - diagnosis Leukemia, Feline - genetics Leukemia, Feline - metabolism Leukemia, Feline - pathology Lymphocytes T Lymphoma, T-Cell - diagnosis Lymphoma, T-Cell - genetics Lymphoma, T-Cell - metabolism Lymphoma, T-Cell - pathology Male Medical Microbiology Myc protein Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Polymerase chain reaction Polymerase Chain Reaction - methods Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Proto-oncogenes T-cell lymphoma T-Lymphocytes - metabolism T-Lymphocytes - pathology Transduction, Genetic Tumors Veterinary medicine Virology |
| title | Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats |
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