Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis

Nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2), a transcription factor that regulates inducible expression of detoxifying enzymes, is critical in preventing N-nitrosobutyl(4-hydroxybutyl)amine (BBN)-induced urinary bladder carcinogenesis. To explore whether Nrf2 and the tumor suppressor...

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Bibliographic Details
Published in:Carcinogenesis (New York) 2007-11, Vol.28 (11), p.2398-2403
Main Authors: Iida, Katsuyuki, Itoh, Ken, Maher, Jonathan M., Kumagai, Yoshito, Oyasu, Ryoichi, Mori, Yukio, Shimazui, Toru, Akaza, Hideyuki, Yamamoto, Masayuki
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biological and medical sciences
Butylhydroxybutylnitrosamine - toxicity
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - toxicity
DNA Primers
Genetic Predisposition to Disease
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Inbred ICR
Mice, Transgenic
Mutation
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - physiology
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - physiology
Tumors
Urinary Bladder Neoplasms - chemically induced
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Summary:Nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2), a transcription factor that regulates inducible expression of detoxifying enzymes, is critical in preventing N-nitrosobutyl(4-hydroxybutyl)amine (BBN)-induced urinary bladder carcinogenesis. To explore whether Nrf2 and the tumor suppressor p53 cooperatively act in tumor prevention, we investigated the susceptibility of Nrf2−/−::p53+/− mice to BBN-induced urinary bladder carcinogenesis. The incidence of BBN-induced urinary bladder carcinoma was 63.0% in Nrf2−/− mice (P = 0.115), 75.8% in p53+/− mice (P
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/bgm146