Lowering of blood pressure after nitrate-rich vegetable consumption is abolished with the co-ingestion of thiocyanate-rich vegetables in healthy normotensive males

A diet rich in vegetables is known to provide cardioprotection. However, it is unclear how the consumption of different vegetables might interact to influence vascular health. This study tested the hypothesis that nitrate-rich vegetable consumption would lower systolic blood pressure but that this e...

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Bibliographic Details
Published in:Nitric oxide 2018-04, Vol.74, p.39-46
Main Authors: Dewhurst-Trigg, Rebecca, Yeates, Toby, Blackwell, Jamie R., Thompson, Christopher, Linoby, Adam, Morgan, Paul T., Clarke, Ida, Connolly, Luke J., Wylie, Lee J., Winyard, Paul G., Jones, Andrew M., Bailey, Stephen J.
Format: Article
Language:English
Subjects:
Adult
Blood Pressure - drug effects
Cross-Over Studies
Entero-salivary circulation
Healthy Volunteers
Humans
Male
Nitrates - blood
Nitrates - metabolism
Nitrates - pharmacology
Nitric oxide
Nitrite
Nutrition
Thiocyanates - blood
Thiocyanates - metabolism
Thiocyanates - pharmacology
Vascular health
Vegetables - chemistry
Vegetables - metabolism
Young Adult
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Summary:A diet rich in vegetables is known to provide cardioprotection. However, it is unclear how the consumption of different vegetables might interact to influence vascular health. This study tested the hypothesis that nitrate-rich vegetable consumption would lower systolic blood pressure but that this effect would be abolished when nitrate-rich and thiocyanate-rich vegetables are co-ingested. On four separate occasions, and in a randomized cross-over design, eleven healthy males reported to the laboratory and consumed a 750 mL vegetable smoothie that was either: low in nitrate (∼0.3 mmol) and thiocyanate (∼5 μmol), low in nitrate and high in thiocyanate (∼72 μmol), high in nitrate (∼4 mmol) and low in thiocyanate and high in nitrate and thiocyanate. Blood pressure as well as plasma and salivary [thiocyanate], [nitrate] and [nitrite] were assessed before and 3 h after smoothie consumption. Plasma [nitrate] and [nitrite] and salivary [nitrate] were not different after consuming the two high-nitrate smoothies, but salivary [nitrite] was higher after consuming the high-nitrate low-thiocyanate smoothie (1183 ± 625 μM) compared to the high-nitrate high-thiocyanate smoothie (941 ± 532 μM; P 
ISSN:1089-8603
1089-8611
DOI:10.1016/j.niox.2018.01.009