Triligustilides A and B: Two Pairs of Phthalide Trimers from Angelica sinensis with a Complex Polycyclic Skeleton and Their Activities

Two pairs of enantiomeric phthalide trimers [(−)/(+) triligustilides A (1a/1b) and (−)/(+) triligustilides B (2a/2b)] with complex polycyclic skeletons simultaneously possessing bridged, fused, and spiro ring systems were isolated from Angelica sinensis, together with two pairs of new phthalide dime...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2018-02, Vol.20 (3), p.884-887
Main Authors: Zou, Jian, Chen, Guo-Dong, Zhao, Huan, Huang, Ying, Luo, Xiang, Xu, Wei, He, Rong-Rong, Hu, Dan, Yao, Xin-Sheng, Gao, Hao
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two pairs of enantiomeric phthalide trimers [(−)/(+) triligustilides A (1a/1b) and (−)/(+) triligustilides B (2a/2b)] with complex polycyclic skeletons simultaneously possessing bridged, fused, and spiro ring systems were isolated from Angelica sinensis, together with two pairs of new phthalide dimers. The biogenetic pathways of new phthalides were proposed, and their bioactivities were also evaluated. This is the first time optically pure polymeric phthalides have been obtained from racemates, and their absolute configurations are reported.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b00017