68Ga-PSMA PET/CT in the evaluation of bone metastases in prostate cancer

Purpose The aims of this retrospective analysis were to compare 68 Ga-PSMA PET findings and low-dose CT findings (120 kV, 30 mA), and to obtain semiquantitative and quantitative 68 Ga-PSMA PET data in patients with prostate cancer (PC) bone metastases. Methods In total, 152 PET/CT scans from 140 pat...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2018-06, Vol.45 (6), p.904-912
Main Authors: Sachpekidis, Christos, Bäumer, P., Kopka, K., Hadaschik, B. A., Hohenfellner, M., Kopp-Schneider, A., Haberkorn, U., Dimitrakopoulou-Strauss, A.
Format: Article
Language:English
Subjects:
Association analysis
Bone cancer
Cardiology
Computed tomography
Diagnostic software
Diagnostic systems
Imaging
Internalization
Lesions
Medical imaging
Medicine
Medicine & Public Health
Metastases
Metastasis
Nuclear Medicine
Oncology
Original Article
Orthopedics
Patients
Pelvis
Plasma levels
Positron emission
Positron emission tomography
Prostate cancer
Radiology
Tomography
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Summary:Purpose The aims of this retrospective analysis were to compare 68 Ga-PSMA PET findings and low-dose CT findings (120 kV, 30 mA), and to obtain semiquantitative and quantitative 68 Ga-PSMA PET data in patients with prostate cancer (PC) bone metastases. Methods In total, 152 PET/CT scans from 140 patients were evaluated. Of these patients, 30 had previously untreated primary PC, and 110 had biochemical relapse after treatment of primary PC. All patients underwent dynamic PET/CT scanning of the pelvis and lower abdomen as well as whole-body PET/CT with 68 Ga-PSMA-11. The PET/CT scans were analysed qualitatively (visually), semiquantitatively (SUV), and quantitatively based on a two-tissue compartment model and a noncompartmental approach leading to the extraction of the fractal dimension. Differences were considered significant for p values
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-018-3936-0