Long‐term pediatric skin eruption‐related hospitalizations in offspring conceived via fertility treatment

• Published in: International journal of dermatology 2018-03, Vol.57 (3), p.317-323
• Main Authors: Krieger, Yuval, Wainstock, Tamar, Sheiner, Eyal, Harlev, Avi, Landau, Daniella, Horev, Amir, Bogdanov‐Berezovsky, Alexander, Walfisch, Asnat
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Birth Weight; Child; Child, Preschool; Children; Congenital defects; Eruptions; Female; Fertility; Fertilization; Fetuses; Gestational Age; Health care facilities; Health risk assessment; Health risks; Hospitalization - statistics & numerical data; Humans; Incidence; Infant; Infant, Newborn; Israel - epidemiology; Kaplan-Meier Estimate; Male; Maternal Age; Morbidity; Neonates; Offspring; Pediatrics; Population studies; Pregnancy; Pregnancy Complications - epidemiology; Proportional Hazards Models; Regression models; Reproductive Techniques, Assisted - statistics & numerical data; Reproductive technologies; Retrospective Studies; Risk Factors; Skin; Skin Diseases - epidemiology; Survival; Time Factors; Young Adult
• ISSN: 0011-9059; 1365-4632
• DOI: 10.1111/ijd.13903

Background Although concerns have been raised regarding the long‐term health risks of offspring conceived following fertility treatments, limited information is available regarding their health status beyond the neonatal period. We aimed to evaluate the risk of long‐term eruptive dermatological morbidity among children born following fertility treatments as compared to those conceived spontaneously. Methods A population‐based cohort study was conducted, including all singleton deliveries occurring between the years 1991 and 2014 at a single tertiary medical center. Fetuses with congenital malformations and multiple gestations were excluded. Children delivered following fertility treatment pregnancies and spontaneous pregnancies were compared. Hospitalizations of the offspring up to the age of 18 years involving cutaneous eruptions were evaluated. A Kaplan–Meier survival curve was used to compare cumulative morbidity incidence and a Cox regression model to control for confounders. Results During the study period, 242,187 singleton deliveries met the inclusion criteria, 1.8% of which were following fertility treatments (n = 4324). Eruptive dermatological morbidity of the offspring up to the age of 18 years was significantly more common in the fertility treatment group (1.5%) as compared to spontaneous pregnancies (1.1%; P = 0.023). The Kaplan–Meier survival curve demonstrated a significantly higher cumulative incidence of eruptive dermatological morbidity following fertility treatments (log‐rank P = 0.007). Using the Cox regression model, while controlling for multiple confounders, fertility treatment was noted as an independent risk factor for long‐term pediatric eruptive dermatological morbidity (adjusted HR = 1.43, CI 1.12–1.83, P = 0.004). Conclusion Singletons conceived via fertility treatments appear to be at an increased risk for long‐term eruptive dermatological morbidity.