Cognitive impairment in rheumatoid arthritis: role of lymphocyte subsets, cytokines and neurotrophic factors

To what extent the cognitive impairment of rheumatoid arthritis (RA) is modulated by autoimmune and/or inflammatory activity is largely unknown. The aim of this study was to investigate the role of peripheral inflammation on cognitive functions of patients with active (Ac-), controlled (Co-) RA and...

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Bibliographic Details
Published in:Clinical rheumatology 2018-05, Vol.37 (5), p.1171-1181
Main Authors: Petersen, Laura E., Baptista, Talita S. A., Molina, Júlia K., Motta, Julia G., do Prado, Aline, Piovesan, Deise M., de Nardi, Tatiana, Viola, Thiago W., Vieira, Érica L. M., Teixeira, Antonio L., Grassi-Oliveira, Rodrigo, Bauer, Moisés Evandro
Format: Article
Language:English
Subjects:
Brain-derived neurotrophic factor
Cognitive ability
Cytokines
Enzyme-linked immunosorbent assay
Flow cytometry
Glial cell line-derived neurotrophic factor
Inflammation
Interleukin 10
Interleukin 2
Interleukin 4
Interleukin 6
Lymphocytes B
Lymphocytes T
Medicine
Medicine & Public Health
Mental depression
Neurotrophic factors
Original Article
Plasma cells
Plasma levels
Regression analysis
Rheumatoid arthritis
Rheumatology
Tumor necrosis factor
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Summary:To what extent the cognitive impairment of rheumatoid arthritis (RA) is modulated by autoimmune and/or inflammatory activity is largely unknown. The aim of this study was to investigate the role of peripheral inflammation on cognitive functions of patients with active (Ac-), controlled (Co-) RA and healthy controls. In a cross-sectional study, 102 RA patients and 30 matched healthy controls were recruited. B and T cell subsets were immunophenotyped by flow cytometry. Plasma cytokines and neurotrophins were measured by flow cytometry and ELISA, respectively. Cognitive performance, depression and stress were evaluated by structured clinical interviews. Generalized linear modeling (GzLM) was used to compare differences between groups and multiple linear regression models were used to explore the predictive value of immune variables on cognitive performance. RA patients had overall cognitive impairment. Of note, the Ac-RA had the poorest performance on digit span (DST) and N-back when compared to Co-RA and control group (DST 9.9 ± 2.1, 12.9 ± 4.2, 15.5 ± 4.7, respectively; N-back 49.2 ± 8.3, 55.5 ± 11.1, 60.8 ± 9.1, respectively, all p  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-018-3990-9