Protective Effectiveness of Inactivated Hantavirus Vaccine Against Hemorrhagic Fever With Renal Syndrome

Abstract As there is no effective treatment against hemorrhagic fever with renal syndrome (HFRS), the development of effective vaccine is important. An inactivated hantavirus vaccine (IHV) has been used in Korea, but there has been controversy regarding its effectiveness. We conducted a case-control...

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Bibliographic Details
Published in:The Journal of infectious diseases 2018-04, Vol.217 (9), p.1417-1420
Main Authors: Jung, Jaehun, Ko, Sung-Jun, Oh, Hong Sang, Moon, Song Mi, Song, Jin-Won, Huh, Kyungmin
Format: Article
Language:English
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Summary:Abstract As there is no effective treatment against hemorrhagic fever with renal syndrome (HFRS), the development of effective vaccine is important. An inactivated hantavirus vaccine (IHV) has been used in Korea, but there has been controversy regarding its effectiveness. We conducted a case-control study to evaluate the vaccine effectiveness (VE) of IHV against HFRS in the Korean military. Unadjusted and adjusted VEs of IHV were 59.1% and 58.9%, respectively. VE was higher in divisions with high incidence of HFRS (unadjusted VE, 71.4%; adjusted VE, 78.7%). Our study demonstrated the moderate effectiveness of IHV in high-risk populations residing in endemic area. In this case-control study among military personnel stationed in endemic area, we demonstrated the protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome (HFRS). Vaccine effectiveness was higher in divisions with high incidence of HFRS.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiy037